GSK270822A

GSK270822A is an inhibitor of G protein-coupled receptor kinase 2 (GRK2, IC50 = 12. µM). It is selective for GRK2 over GRK1, GRK5, and PKA (IC50s = 794, 63. and 50. µM, respectively). InChI: InChI=1S/C24H20N4O2/c1-14-23(24(30)27-19-8-9-21-18(11-19)13-25-28-21)20(12-22(29)26-14)17-7-6-15-4-2-3-5-16(15)10-17/h2-11,13,20H,12H2,1H3,(H,25,28)(H,26,29)(H,27,30), InChIKey: ODLNBFNBEPOFNC-UHFFFAOYSA-N, SMILES: O=C(CC1C2=CC3=C(C=CC=C3)C=C2)NC(C)=C1C(NC4=CC5=C(C=C4)NN=C5)=O