GSK2250665A

GSK2250665A is an IL-2-inducible T cell kinase (Itk) inhibitor (IC50 = 0.63 nM). It is selective for Itk over Aurora B kinase (IC50 = 398 nM) and a panel of 11 kinases (IC50s = 4-631 nM). GSK2250665A reduces the levels of IFN-gamma in isolated human peripheral blood mononuclear cells (PBMCs, IC50 = 25 nM).. SMILES: O[C@@H](CC1)CC[C@H]1NC2=NC(CC3=CC=CC=C3)=CC(NC4=NC5=CC=C(CC)C=C5S4)=N2. InChi Code: InChI=1S/C26H29N5OS/c1-2-17-8-13-22-23(15-17)33-26(29-22)31-24-16-20(14-18-6-4-3-5-7-18)28-25(30-24)27-19-9-11-21(32)12-10-19/h3-8,13,15-16,19,21,32H,2,9-12,14H2,1H3,(H2,27,28,29,30,31)/t19-,21-. InChi Key: DPRNXTSMYVCYLJ-XUTJKUGGSA-N