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NEU
GSK2250665A
Artikelnummer: Cay45942-1
GSK2250665A is an IL-2-inducible T cell kinase (Itk) inhibitor (IC50 = 0.63 nM). It is selective for Itk over Aurora B kinase (IC50 = 398 nM) and a panel of 11 kinases (IC50s = 4-631 nM). GSK2250665A reduces the levels of IFN-gamma in isolated human peripheral blood mononuclear cells (PBMCs, IC50 = 25 nM).. SMILES:...
| Schlagworte: | trans-4-[[4-[(6-ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]-cyclohexanol |
| Anwendung: | ITK inhibitor |
| CAS | 1246030-96-5 |
| MW: | 459.61 D |
ab 91,00 €
GSK-2250665A
Artikelnummer: TGM-T27458-5mg
Description: GSK-2250665A is a Itk inhibitor with pKi value of 9.2. Target: Others. Smiles: N(C=1SC=2C(N1)=CC=C(CC)C2)C3=NC(N[C@H]4CC[C@H](O)CC4)=NC(CC5=CC=CC=C5)=C3. References: Alder et al (2013) Identification of a novel and selective series of Itk inhibitors via a template-hopping strategy. ACS Med.Chem.Lett. 12...
| Schlagworte: | GSK 2250665, GSK2250665, GSK-2250665, GSK 2250665A |
| CAS | 1246030-96-5 |
| MW: | 459.61 D |
566,00 €
