GBR 13069 (hydrochloride)

GBR 13069 is a dopamine uptake inhibitor. It selectively inhibits dopamine uptake over norepinephrine uptake in rat occipital cortex slices (IC50s = 40 and 800 nM, respectively). GBR 13069 (2.5, 5, and 10 mg/kg) induces ipsilateral rotation and increases locomotion in rats. It also prevents 2'-CH3-MPTP-induced decreases in neostriatal levels of the endogenous catecholamine dopamine (Cay-36532) and its metabolites DOPAC (3,4-dihydroxyphenylacetic acid, Cay-24912) and homovanillic acid (HVA, Cay-27307) in mice when administered at a dose of 5 mg/kg.Formal Name: 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propen-1-yl)-piperazine, dihydrochloride. CAS Number: 67469-45-8. Molecular Formula: C28H30F2N2O . 2HCl. Formula Weight: 521.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml. lambdamax: 254 nm. SMILES: FC1=CC=C(C(C2=CC=C(C=C2)F)OCCN3CCN(CC3)CC=CC4=CC=CC=C4)C=C1.Cl.Cl. InChi Code: InChI=1S/C28H30F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23,,/h1-15,28H,16-22H2,2*1H. InChi Key: ZBSZWEYIIGLGSX-UHFFFAOYSA-N.