GBR 12783 (hydrochloride)

GBR 12783 is a dopamine uptake inhibitor (IC50 = 13 nM in rat striatal synaptosomes). It is selective for inhibition of dopamine uptake over norepinephrine or serotonin (5-HT) uptake (IC50s = 230 and 1,100 nM in rat hypothalamic and striatal synaptosomes, respectively). GBR 12783 (10 mg/kg, i.p.) improves learning and memory in the passive avoidance test in rats, an effect that can be blocked by the anticholinergic agent scopolamine. It increases locomotor activity, reduces pentobarbital-induced sleep duration, and decreases immobility time in the forced swim test, in mice. GBR 12783 (10 mg/kg) inhibits catalepsy induced by the antipsychotic haloperidol (Cay-12014) in rats.Formal Name: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-piperazine, dihydrochloride. CAS Number: 67469-75-4. Synonyms: Lu 2-098, MW-486. Molecular Formula: C28H32N2O . 2HCl. Formula Weight: 485.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, DMSO: Soluble. SMILES: N1(CCN(CC1)CC=CC2=CC=CC=C2)CCOC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl. InChi Code: InChI=1S/C28H32N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27,,/h1-17,28H,18-24H2,2*1H. InChi Key: HJDXBLLTRMCYNC-UHFFFAOYSA-N.