Galantamine-d3 (hydrobromide)

Galantamine-d3 is intended for use as an internal standard for the quantification of galantamine by GC- or LC-MS. Galantamine is an alkaloid originally isolated from the bulbs and flowers of Galanthus that inhibits acetylcholinesterase (AChE, IC50 = 636 nM). It reverses growth inhibition and inhibits apoptosis, autophagic flux, and production of reactive oxygen species (ROS) induced by amyloid-beta (Abeta) in neuronally differentiated PC12 cells. Galantamine prevents soman toxicity and inhibits acetylcholinesterase in cynomolgus macaques (ED50s = 590 and 362 µg/kg, respectively). It also decreases escape latency in the Morris water maze and the total hippocampal area of Abeta plaques in an APP/PS1 transgenic mouse model of Alzheimer's disease.Formal Name: (4aS,6R,8aS)-3-(methoxy-d3)-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol, monohydrobromide. CAS Number: 2140262-53-7. Molecular Formula: C17H18D3NO3 . HBr. Formula Weight: 371.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble. SMILES: O[C@H]1C=C[C@]23[C@](OC4=C2C(CN(C)CC3)=CC=C4OC([2H])([2H])[2H])([H])C1.Br. InChi Code: InChI=1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17,/h3-6,12,14,19H,7-10H2,1-2H3,1H/t12-,14-,17-,/m0./s1/i2D3,. InChi Key: QORVDGQLPPAFRS-VKZDZIIGSA-N.