FR180204

FR180204 is a potent cell-permeable inhibitor of ERK1 and ERK2 (Ki = 310 and 140 nM, respectively). It is much less effective against p38alpha (IC50 = 10 µM) and does not inhibit a range of other serine/threonine or tyrosine kinases. FR180204 blocks ERK-mediated signaling from TGF-beta to AP-1 (IC50 = 3.1 µM). It attenuates delayed-type hypersensitivity in collagen-immunized mice and ameliorates collagen-induced arthritis in mice.Formal Name: 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine. CAS Number: 865362-74-9. Synonyms: ERK Inhibitor II. Molecular Formula: C18H13N7. Formula Weight: 327.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 25 mg/ml. lambdamax: 252, 299, 409 nm. SMILES: NC1=NNC(N=N2)=C1C=C2C3=C4N(N=C3C5=CC=CC=C5)C=CC=C4. InChi Code: InChI=1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23). InChi Key: XVECMUKVOMUNLE-UHFFFAOYSA-N.