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FR180204
Artikelnummer: Cay15544-1
FR180204 is a potent cell-permeable inhibitor of ERK1 and ERK2 (Ki = 310 and 140 nM, respectively). It is much less effective against p38alpha (IC50 = 10 µM) and does not inhibit a range of other serine/threonine or tyrosine kinases. FR180204 blocks ERK-mediated signaling from TGF-beta to AP-1 (IC50 = 3.1 µM). It...
| Schlagworte: | ERK Inhibitor II, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine |
| Anwendung: | Cell-permeable ERK1 / ERK2 inhibitor |
| CAS | 865362-74-9 |
| MW: | 327.3 D |
ab 93,00 €
FR 180204
Artikelnummer: TGM-T1956-100mg
Description: FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2. Target: ERK, Apoptosis. Smiles: NC=1C2=CC(C=3C(=NN4C3C=CC=C4)C5=CC=CC=C5)=NN=C2NN1. References: Ohori M, et al. Biochem Biophys Res Commun. 2005, 336(1), 357-363.
| Schlagworte: | FR180204 |
| Anwendung: | Cell-permeable ERK1 / ERK2 inhibitor |
| CAS | 865362-74-9 |
| MW: | 327.34 D |
ab 35,00 €
