FG-2216

FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.Formal Name: N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-glycine. CAS Number: 223387-75-5. Synonyms: IOX3, YM-311. Molecular Formula: C12H9ClN2O4. Formula Weight: 280.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 221, 257, 327, 341 nm. SMILES: OC1=C(C(NCC(O)=O)=O)N=C(Cl)C2=CC=CC=C21. InChi Code: InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17). InChi Key: OUQVKRKGTAUJQA-UHFFFAOYSA-N.