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FG-2216
Artikelnummer: Cay18382-5
FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.Formal Name:...
| Schlagworte: | IOX3, YM-311, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-glycine |
| Anwendung: | HIF-prolyl hydroxylase inhibitor |
| CAS | 223387-75-5 |
| MW: | 280.7 D |
ab 69,00 €
FG-2216
Artikelnummer: TGM-T2445-100mg
Description: FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM), orally bioavailable and induced reversible and significant Epo induction in vivo. Target: HIF/HIF Prolyl-Hydroxylase. Smiles: OC(=O)CNC(=O)c1nc(Cl)c2ccccc2c1O. References: Hong YR, et al. Bioorg Med Chem...
| Schlagworte: | YM-311, FG2216, FG 2216 |
| CAS | 223387-75-5 |
| MW: | 280.66 D |
ab 30,00 €
