Fenobam (hydrate)

Fenobam is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5) that binds to an allosteric site. It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate (Cay-20211) in HEK293 cells expressing the human receptor (IC50 = 58 nM) and inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM). Fenobam (10 and 30 mg/kg) reduces stress-induced hyperthermia in mice and increases drinking time in the Vogel conflict test in rats when administered at a dose of 30 mg/kg, indicating anxiolytic-like activity. It induces analgesia in the formalin test in mice when administered at a dose of 30 mg/kg.Formal Name: N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)-urea, monohydrate. CAS Number: 63540-28-3. Molecular Formula: C11H11ClN4O2 . H2O. Formula Weight: 284.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM. lambdamax: 214, 271 nm. SMILES: ClC1=CC=CC(NC(NC(N(C)C2)=NC2=O)=O)=C1.O. InChi Code: InChI=1S/C11H11ClN4O2.H2O/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8,/h2-5H,6H2,1H3,(H2,13,14,15,17,18),1H2. InChi Key: UNFQKKSADLVQJE-UHFFFAOYSA-N.