EX 527

Artikelnummer	Größe	Datenblatt	Manual	SDB	Lieferzeit	Menge	Preis
LKT-E9201.5	5 mg		-		3 - 8 Werktage*		135,00 €
LKT-E9201.25	25 mg		-		3 - 8 Werktage*		405,00 €

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EX 527 is an inhibitor of sirtuin 1 (SIRT1), sirtuins are considered class III histone... mehr

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Produktinformationen "EX 527"

EX 527 is an inhibitor of sirtuin 1 (SIRT1), sirtuins are considered class III histone deacetylases (HDACs). EX 527 binds the NAD+ site of sirtuin 1, stabilizing a closed conformation. EX 527 exhibits immunostimulatory and anti-inflammatory activities. In animal models of autoimmune colitis and inflammatory bowel disease, EX 527 increases the number of Foxp3+ Treg cells and prevents weight loss. In animal models of polycystic kidney disease, this compound delays renal cyst formation and growth. Additionally, EX 527 improves myocardial histology and increases the number of Foxp3+ Treg cells in animal models of transplant surgery, prolonging allograft survival.

Schlagworte:	Selisistat
Hersteller:	LKT Laboratories
Hersteller-Nr:	E9201

Eigenschaften

Anwendung:	SIRT1 inhibitor
MW:	248.71 D
Reinheit:	>98%
Format:	Solid

Datenbank Information

CAS :	49843-98-3\| Passende Produkte
KEGG ID :	K11411 \| Passende Produkte

Handhabung & Sicherheit

Lagerung:	+20°C
Versand:	+20°C (International: +20°C)
Signalwort:	Danger
GHS-Piktogramme:
H-Sätze:	H301, H319
P-Sätze:	P264, P280, P330, P301+P310, P305+P351+P338, P337+P313