Zu "K11411" wurden 175 Artikel gefunden!
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SRT 1720
Artikelnummer: Cay42531-10
A SIRT1 activator (EC1.5 = 0.16 µM in a cell-free fluorescence polarization assay), reduces acetylated p53 levels in U2OS cells at 0.1 µM, reduces fed blood glucose levels, improves insulin sensitivity, and increases mitochondrial capacity in a DIO mouse model of diabetes at 100 mg/kg, improves liver, adipose...
| Schlagworte: | CAY10559, SIRT 1933, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide |
| Anwendung: | SIRT1 activator |
| CAS | 925434-55-5 |
| MW: | 469.56 D |
ab 82,00 €
SIRT1 Direct Fluorescent Screening Assay Kit
Artikelnummer: Cay10010401-96
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast Silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1,...
| Schlagworte: | SIRT1, hSIR2, hSIRT1, SIR2L1, EC=3.5.1.-, SIR2-like protein 1, NAD-dependent deacetylase sirtuin-1 |
| Anwendung: | SIRT1 inhibitor/activator screening |
| Spezies-Reaktivität: | human |
533,00 €
SRT 2183
Artikelnummer: Cay43526-10
SRT 2183 is an activator of sirtuin 1 (SIRT1, EC50 = 0.36 µM). However, it was found only to bind fluorophore-labeled SIRT1 and also inhibits 14 targets, including cannabinoid receptor 1 (CB1), adenosine receptor 3 (A3), and phosphodiesterase 5 (PDE5), in a panel of 100 receptors, enzymes, ion channels, and...
| Schlagworte: | N-[2-[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]-2-naphthalenecarboxamide |
| Anwendung: | SIRT1 activator |
| CAS | 1001908-89-9 |
| MW: | 468.58 D |
ab 193,00 €
Fluorogenic SIRT1 (Sir2) Assay Kit
Artikelnummer: BPS-50081
The Fluorogenic SIRT1 Assay Kit is a complete assay system designed to measure Sirtuin 1 (SIRT1) activity for screening and profiling Applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent SIRT1 (Sir2) activity measurements. In addition, the kit includes purified...
| Schlagworte: | SIR2L1, |
| Anwendung: | Enzyme kinetics, inhibitor screening, HTS |
700,00 €
(±)-EX-527
Artikelnummer: Cay10009798-5
EX-527 is an inhibitor of sirtuin 1 (SIRT1, IC50 = 0.098 µM). It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7...
| Schlagworte: | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Anwendung: | SIRT1 inhibitor |
| CAS | 49843-98-3 |
| MW: | 248.7 D |
ab 51,00 €
Fisetin
Artikelnummer: Cay15246-100
Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities. It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP, Cay-21495) in isolated human...
| Schlagworte: | CI-75620, NSC 407010, NSC 656275, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one |
| Anwendung: | Sirtuin 1 activator, antioxidant |
| CAS | 528-48-3 |
| MW: | 286.2 D |
ab 53,00 €
CAY10591
Artikelnummer: Cay10009797-1
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1,...
| Schlagworte: | SIRT1 Activator 3, Sirtuin 1 Activator 3,... |
| Anwendung: | SIRT1 assays |
| CAS | 839699-72-8 |
| MW: | 367.5 D |
ab 45,00 €
Anti-SIRT1 Monoclonal Antibody
Artikelnummer: E-AN200054P.100
SIRT1 (SIR2-like protein 1, also NAD-dependent protein deacetylase sirtuin-1 and hSIR2) is a class I member of the sirtuin family of enzymes. Although its predicted MW is 81 kDa, it runs anomalously at 110-120 kDa in SDS-PAGE. It is a widely expressed nuclear protein that participates in the deacetylation of...
| Schlagworte: | SIR2L1, SIRT1 Monoclonal Antibody |
| Anwendung: | IHC (paraffin), ICC/IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
389,00 €
Sirtuin 1, active human recombinant protein
Artikelnummer: BPS-50012
Active human Sirtuin 1 , GenBank Accession No. NM_012238), amino acids 193- 741 with N-terminal GST tag, MW= 87.2 kDa, expressed in E. coli expression system.
| Schlagworte: | SIR2L1, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 87.2 kD |
663,00 €
SRT 1720 (hydrochloride)
Artikelnummer: Cay10011020-1
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1,...
| Schlagworte: | CAY10559, SIRT 1933, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide, hydrochloride |
| Anwendung: | SIRT1 activator |
| CAS | 1001645-58-4 |
| MW: | 469.6 D |
ab 60,00 €
SIRT1 (human, recombinant)
Artikelnummer: Cay10011190-100
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins,...
| Schlagworte: | hSIR2, SIR2L1, hSIRT1, 75SirT1, SIR2-like protein 1, SirtT1 75 kDa fragment, Regulatory protein SIR2 homolog 1,... |
| Anwendung: | Enzyme activity |
| MW: | 89,2 kD |
734,00 €
Resveratrol
Artikelnummer: CDX-R0057-M100
White to off-white powder. Soluble in ethanol, DMSO, acetone or water (3 mg/100 ml). Selective inhibitor of COX?1. Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase involved in mitochondrial...
| Schlagworte: | 3,4',5-Trihydroxy-trans-stilbene |
| Anwendung: | Selective COX?1 inhibitor, antioxidant, SIRT1 activator |
| CAS | 501-36-0 |
| MW: | 228,24 D |
ab 77,00 €