Zu "K11411" wurden 163 Artikel gefunden!
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SIRT1 Direct Fluorescent Screening Assay Kit
Artikelnummer: Cay10010401-96
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast Silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1,...
| Schlagworte: | SIRT1, hSIR2, hSIRT1, SIR2L1, EC=3.5.1.-, SIR2-like protein 1, NAD-dependent deacetylase sirtuin-1 |
| Anwendung: | SIRT1 inhibitor/activator screening |
| Spezies-Reaktivität: | human |
516,00 €
SRT 2183
Artikelnummer: Cay43526-10
SRT 2183 is an activator of sirtuin 1 (SIRT1, EC50 = 0.36 µM). However, it was found only to bind fluorophore-labeled SIRT1 and also inhibits 14 targets, including cannabinoid receptor 1 (CB1), adenosine receptor 3 (A3), and phosphodiesterase 5 (PDE5), in a panel of 100 receptors, enzymes, ion channels, and...
| Schlagworte: | N-[2-[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]-2-naphthalenecarboxamide |
| Anwendung: | SIRT1 activator |
| CAS | 1001908-89-9 |
| MW: | 468.58 D |
ab 186,00 €
Anti-SIRT1 Monoclonal Antibody
Artikelnummer: E-AN200054P.100
SIRT1 (SIR2-like protein 1, also NAD-dependent protein deacetylase sirtuin-1 and hSIR2) is a class I member of the sirtuin family of enzymes. Although its predicted MW is 81 kDa, it runs anomalously at 110-120 kDa in SDS-PAGE. It is a widely expressed nuclear protein that participates in the deacetylation of...
| Schlagworte: | SIR2L1, SIRT1 Monoclonal Antibody |
| Anwendung: | IHC (paraffin), ICC/IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
389,00 €
Fluorogenic SIRT1 (Sir2) Assay Kit
Artikelnummer: BPS-50081
The Fluorogenic SIRT1 Assay Kit is a complete assay system designed to measure Sirtuin 1 (SIRT1) activity for screening and profiling Applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent SIRT1 (Sir2) activity measurements. In addition, the kit includes purified...
| Schlagworte: | SIR2L1, |
| Anwendung: | Enzyme kinetics, inhibitor screening, HTS |
700,00 €
(±)-EX-527
Artikelnummer: Cay10009798-5
EX-527 is an inhibitor of sirtuin 1 (SIRT1, IC50 = 0.098 µM). It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7...
| Schlagworte: | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Anwendung: | SIRT1 inhibitor |
| CAS | 49843-98-3 |
| MW: | 248.7 D |
ab 49,00 €
Fisetin
Artikelnummer: Cay15246-100
Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities. It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP, Cay-21495) in isolated human...
| Schlagworte: | CI-75620, NSC 407010, NSC 656275, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one |
| Anwendung: | Sirtuin 1 activator, antioxidant |
| CAS | 528-48-3 |
| MW: | 286.2 D |
ab 50,00 €
CAY10591
Artikelnummer: Cay10009797-1
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1,...
| Schlagworte: | SIRT1 Activator 3, Sirtuin 1 Activator 3,... |
| Anwendung: | SIRT1 assays |
| CAS | 839699-72-8 |
| MW: | 367.5 D |
ab 44,00 €
Sirtuin 1, active human recombinant protein
Artikelnummer: BPS-50012
Active human Sirtuin 1 , GenBank Accession No. NM_012238), amino acids 193- 741 with N-terminal GST tag, MW= 87.2 kDa, expressed in E. coli expression system.
| Schlagworte: | SIR2L1, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 87.2 kD |
663,00 €
SRT 1720 (hydrochloride)
Artikelnummer: Cay10011020-1
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1,...
| Schlagworte: | CAY10559, SIRT 1933, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide, hydrochloride |
| Anwendung: | SIRT1 activator |
| CAS | 1001645-58-4 |
| MW: | 469.6 D |
ab 58,00 €
SIRT1 (human, recombinant)
Artikelnummer: Cay10011190-100
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins,...
| Schlagworte: | hSIR2, SIR2L1, hSIRT1, 75SirT1, SIR2-like protein 1, SirtT1 75 kDa fragment, Regulatory protein SIR2 homolog 1,... |
| Anwendung: | Enzyme activity |
| MW: | 89,2 kD |
712,00 €
Resveratrol
Artikelnummer: CDX-R0057-M100
White to off-white powder. Soluble in ethanol, DMSO, acetone or water (3 mg/100 ml). Selective inhibitor of COX?1. Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase involved in mitochondrial...
| Schlagworte: | 3,4',5-Trihydroxy-trans-stilbene |
| Anwendung: | Selective COX?1 inhibitor, antioxidant, SIRT1 activator |
| CAS | 501-36-0 |
| MW: | 228,24 D |
ab 77,00 €
Anti-phospho-SIRT1 (Ser47)
Artikelnummer: CSB-PA857953.100
Protein function: NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523,...
| Schlagworte: | Anti-phospho-SIR2L1, Phospho-SIRT1 (Ser47) Antibody |
| Anwendung: | ELISA, WB |
| Spezies-Reaktivität: | human |
340,00 €