Zu "K11411" wurden 176 Artikel gefunden!
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NEU
Mouse SIRT1 (Sirtuin 1) Microsample ELISA Kit
Artikelnummer: ELK-ELK6397MS.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse SIRT1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse SIRT1. Next,...
| Schlagworte: | Sirt1, SIR2alpha, SIR2-like protein 1, Regulatory protein SIR2 homolog 1, NAD-dependent protein deacylase sirtuin-1,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 374,00 €
NEU
Human SIRT1 (Sirtuin 1) Microsample ELISA Kit
Artikelnummer: ELK-ELK10541MS.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human SIRT1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human SIRT1. Next,...
| Schlagworte: | SIRT1, SIR2-like protein 1, Regulatory protein SIR2 homolog 1, NAD-dependent protein deacylase sirtuin-1, NAD-dependent... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
Anti-phospho-SIRT1 (pSer47) / Sirtuin 1, clone FDA-19
Artikelnummer: NSJ-FY13408
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Sirtuin 1 (SIRT1) is a NAD-dependent deacetylase involved in regulation of chromatin organization, metabolic adaptation, oxidative stress signaling, and cellular survival pathways. Phospho-SIRT1...
| Schlagworte: | Anti-phospho-SIRT1, Anti-phospho-SIR2-like protein 1, Anti-phospho-Regulatory protein SIR2 homolog 1,... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-phospho-SIRT1 (pThr530), clone HAI-19
Artikelnummer: NSJ-FY13407
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Sirtuin 1 (SIRT1) is a NAD-dependent protein deacetylase involved in regulation of metabolic adaptation, chromatin signaling, oxidative stress responses, and cellular survival pathways. Phospho-SIRT1...
| Schlagworte: | Anti-phospho-SIRT1, Anti-phospho-SIR2-like protein 1, Anti-phospho-Regulatory protein SIR2 homolog 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
SRT 1720
Artikelnummer: Cay42531-10
A SIRT1 activator (EC1.5 = 0.16 µM in a cell-free fluorescence polarization assay), reduces acetylated p53 levels in U2OS cells at 0.1 µM, reduces fed blood glucose levels, improves insulin sensitivity, and increases mitochondrial capacity in a DIO mouse model of diabetes at 100 mg/kg, improves liver, adipose...
| Schlagworte: | CAY10559, SIRT 1933, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide |
| Anwendung: | SIRT1 activator |
| CAS | 925434-55-5 |
| MW: | 469.56 D |
ab 82,00 €
SIRT1 Direct Fluorescent Screening Assay Kit
Artikelnummer: Cay10010401-96
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast Silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1,...
| Schlagworte: | SIRT1, hSIR2, hSIRT1, SIR2L1, EC=3.5.1.-, SIR2-like protein 1, NAD-dependent deacetylase sirtuin-1 |
| Anwendung: | SIRT1 inhibitor/activator screening |
| Spezies-Reaktivität: | human |
533,00 €
Fluorogenic SIRT1 (Sir2) Assay Kit
Artikelnummer: BPS-50081
The Fluorogenic SIRT1 Assay Kit is a complete assay system designed to measure Sirtuin 1 (SIRT1) activity for screening and profiling Applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent SIRT1 (Sir2) activity measurements. In addition, the kit includes purified...
| Schlagworte: | SIR2L1, |
| Anwendung: | Enzyme kinetics, inhibitor screening, HTS |
700,00 €
(±)-EX-527
Artikelnummer: Cay10009798-5
EX-527 is an inhibitor of sirtuin 1 (SIRT1, IC50 = 0.098 µM). It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7...
| Schlagworte: | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Anwendung: | SIRT1 inhibitor |
| CAS | 49843-98-3 |
| MW: | 248.7 D |
ab 51,00 €
Fisetin
Artikelnummer: Cay15246-100
Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities. It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP, Cay-21495) in isolated human...
| Schlagworte: | CI-75620, NSC 407010, NSC 656275, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one |
| Anwendung: | Sirtuin 1 activator, antioxidant |
| CAS | 528-48-3 |
| MW: | 286.2 D |
ab 53,00 €
CAY10591
Artikelnummer: Cay10009797-1
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1,...
| Schlagworte: | SIRT1 Activator 3, Sirtuin 1 Activator 3,... |
| Anwendung: | SIRT1 assays |
| CAS | 839699-72-8 |
| MW: | 367.5 D |
ab 45,00 €
Sirtuin 1, active human recombinant protein
Artikelnummer: BPS-50012
Active human Sirtuin 1 , GenBank Accession No. NM_012238), amino acids 193- 741 with N-terminal GST tag, MW= 87.2 kDa, expressed in E. coli expression system.
| Schlagworte: | SIR2L1, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 87.2 kD |
663,00 €
Resveratrol
Artikelnummer: CDX-R0057-M100
White to off-white powder. Soluble in ethanol, DMSO, acetone or water (3 mg/100 ml). Selective inhibitor of COX?1. Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase involved in mitochondrial...
| Schlagworte: | 3,4',5-Trihydroxy-trans-stilbene |
| Anwendung: | Selective COX?1 inhibitor, antioxidant, SIRT1 activator |
| CAS | 501-36-0 |
| MW: | 228,24 D |
ab 77,00 €