DS12881479

DS12881479 is an inhibitor of MAP kinase-interacting serine/threonine protein kinase 1 (MNK1, IC50s = 21 and 416 nM for the inactive and active forms, respectively). It is selective for MNK1 over 46 other kinases but does inhibit FMS-related tyrosine kinase 3 (FLT3) and dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) at 5 µM. InChI: InChI=1S/C16H19N3OS/c1-19-9-7-13(8-10-19)15(20)18-16-17-11-14(21-16)12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3,(H,17,18,20), InChIKey: BTZKRRFKIKIADV-UHFFFAOYSA-N, SMILES: CN1CCC(C(NC(S2)=NC=C2C3=CC=CC=C3)=O)CC1