Droxinostat

Droxinostat is an inhibitor of histone deacetylase (HDAC) 3, 6, and 8 (IC50s = 16.9, 2.47, and 1.46 µM, respectively). It is selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 µM). Droxinostat increases histone H3 and H4 acetylation in PPC-1 prostate, OVCAR3 ovarian, U937 leukemia, HT-29 colon, and T47D breast cancer cells. It also inhibits proliferation and colony formation of SMMC-7721 and HepG2 hepatocellular carcinoma cell lines via activation of mitochondrial apoptosis and reduction of cellular FLICE-inhibitory protein (c-FLIP).Formal Name: 4-(4-chloro-2-methylphenoxy)-N-hydroxy-butanamide. CAS Number: 99873-43-5. Synonyms: NS 41080. Molecular Formula: C11H14ClNO3. Formula Weight: 243.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH7.2)(1:20): 0.05 mg/ml. lambdamax: 231, 281 nm. SMILES: ClC1=CC(C)=C(OCCCC(NO)=O)C=C1. InChi Code: InChI=1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14). InChi Key: JHSXDAWGLCZYSM-UHFFFAOYSA-N.