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Droxinostat
Artikelnummer: Cay23869-1
Droxinostat is an inhibitor of histone deacetylase (HDAC) 3, 6, and 8 (IC50s = 16.9, 2.47, and 1.46 µM, respectively). It is selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 µM). Droxinostat increases histone H3 and H4 acetylation in PPC-1 prostate, OVCAR3 ovarian, U937 leukemia, HT-29 colon,...
| Schlagworte: | NS 41080, 4-(4-chloro-2-methylphenoxy)-N-hydroxy-butanamide |
| Anwendung: | HDAC3/6/8 inhibitor |
| CAS | 99873-43-5 |
| MW: | 243.7 D |
ab 50,00 €
Droxinostat
Artikelnummer: TGM-T6481-100mg
Description: Droxinostat (NS 41080) is a selective HDAC inhibitor, primarily targeting HDACs 6 and 8 with IC50 values of 2.47 µM and 1.46 µM, respectively. It is over 8-fold more selective against HDAC3 and shows no inhibition for HDAC1, 2, 4, 5, 7, 9, and 10. Target: Apoptosis, HDAC. Smiles:...
| Schlagworte: | NS 41080 |
| Anwendung: | HDAC3/6/8 inhibitor |
| CAS | 99873-43-5 |
| MW: | 243.69 D |
ab 29,00 €
