DPQ

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can be used in either cells or in animals.Formal Name: 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone. CAS Number: 129075-73-6. Synonyms: PARP Inhibitor III. Molecular Formula: C18H26N2O2. Formula Weight: 302.4. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C1NCCC2=C(OCCCCN3CCCCC3)C=CC=C21. InChi Code: InChI=1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21). InChi Key: RVOUDNBEIXGHJY-UHFFFAOYSA-N.