DL-3,4-Dihydroxyphenyl glycol

DL-3,4-Dihydroxyphenyl glycol is an active metabolite of the endogenous neurotransmitter norepinephrine (Cay-35580). It is produced by the deamination of norepinephrine by monoamine oxidase (MAO) in the cytosol. DL-3,4-Dihydroxyphenyl glycol scavenges DPPH (Cay-14805) radicals in a cell-free assay (IC50 = 1.55 µM). It reduces LPS-induced nitrite production in isolated mouse peritoneal macrophages when used at concentrations of 50 and 100 µM. DL-3,4-Dihydroxyphenyl glycol (50 and 100 µM) decreases increases in inducible nitric oxide synthase (iNOS) and COX-2 levels induced by LPS in isolated mouse macrophages. It also inhibits LPS-induced degradation of IkappaBalpha in isolated mouse macrophages.Formal Name: 4-(1,2-dihydroxyethyl)-1,2-benzenediol. CAS Number: 28822-73-3. Synonyms: Ba 2775, DHPG, NSC 92532. Molecular Formula: C8H10O4. Formula Weight: 170.6. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: OC1=CC=C(C(CO)O)C=C1O. InChi Code: InChI=1S/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2. InChi Key: MTVWFVDWRVYDOR-UHFFFAOYSA-N.