Zu "K00274" wurden 178 Artikel gefunden!
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NEU
Iproniazid
Artikelnummer: Cay45450-100
Iproniazid is an inhibitor of monoamine oxidase A (MAO-A) and MAO-B (IC50s = 6.56 and 7.54 µM, respectively). It reduces immobility in an open swimming test in rats, indicating antidepressant-like activity, when administered at a dose of 10 mg/kg. Iproniazid (300 and 400 mg/kg) induces acute hepatic necrosis in...
| Schlagworte: | 2-(1-methylethyl)hydrazide, 4-pyridinecarboxylic acid |
| Anwendung: | MAO-A / MAO-B inhibitor |
| CAS | 54-92-2 |
| MW: | 179.22 D |
ab 35,00 €
NEU
Monoamine Oxidase A (MAO-A) Inhibitor Screening...
Artikelnummer: BPS-83909
Monoamine Oxidase A (MAO-A) Inhibitor Screening Fluorogenic Assay Kit is designed to measure human MAO-A activity for screening and profiling applications based on the fluorometric detection of H2O2, one of the byproducts generated during the oxidative deamination of MAO-A substrates. The assay kit comes in a...
| Schlagworte: | MAOA, Amine oxidase [flavin-containing] A, Monoamine oxidase type A |
| Anwendung: | Enzyme kinetics, small molecule inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
804,00 €
Anti-Recombinant MAO-A, clone A611
Artikelnummer: E-AN301895L.100
Monoamine oxidase A (MAO-A), a mitochondrial enzyme, catalyzes the degradation of monoamines. Studies show that increased expression of MAO-A promotes prostate cancer metastasis by activating the Shh-IL6-RANKL signaling network. In addition, MAO-A expression in adipose tissue macrophages is upregulated in aging,...
| Schlagworte: | Anti-MAOA, Anti-Monoamine oxidase type A, Anti-Amine oxidase [flavin-containing] A, Recombinant MAO-A Monoclonal Antibody |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 304,00 €
Bifemelane (hydrochloride)
Artikelnummer: Cay43732-10
Bifemelane is an inhibitor of monoamine oxidase A (MAO-A, Ki = 4.2 µM). It is selective for MAO-A over MAO-B (Ki = 46 µM). Bifemelane (15 mg/kg, p.o.) protects against ischemia-induced decreases in frontal cortex, hippocampus, and striatum levels of muscarinic acetylcholine receptors (mAChRs) in a rat model of...
| Schlagworte: | 4-(O-Benzylphenoxy)-N-methylbutylamine, BP-N-Methylbutylamine, MCI-2016,... |
| Anwendung: | MAO-A inhibitor |
| CAS | 62232-46-6 |
| MW: | 305.85 D |
ab 107,00 €
Pirlindole
Artikelnummer: Cay22060-1
A selective and reversible MAO-A inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively), selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively), reverses the depressive-like effects induced by CMS, increases hippocampal cell proliferation,...
| Schlagworte: | 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole |
| Anwendung: | MAO-A inhibitor |
| CAS | 60762-57-4 |
| MW: | 226.3 D |
82,00 €
ORY-2001
Artikelnummer: Cay43663-1
An LSD1 and MAO-B inhibitor (IC50s = 0.101 and 0.073 µM, respectively), selective for LSD1 and MAO-B over MAO-A (IC50 = 5.47 µM) and LSD2, SMOX, and LAAO at 10 µM, as well as a panel of 19 additional epigenetic targets and a panel of 92 receptors, ion channels, enzymes, and transporters at 10 µM, induces...
| Schlagworte: | Vafidemstat, 5-amino-N-[(1R,2S)-2-[4-(phenylmethoxy)phenyl]cyclopropyl]-1,3,4-oxadiazole-2-methanamine |
| Anwendung: | LSD1 / MAO-B inhibitor |
| CAS | 1357362-02-7 |
| MW: | 336.4 D |
ab 70,00 €
(R)-(-)-Pirlindole (mesylate)
Artikelnummer: Cay43879-1
An inhibitor of MAO-A (IC50 = 0.43 µM), selective for MAO-A over MAO-B, decreases immobility time in the forced swim test in mice at 50 mg/kg, inhibits reserpine-induced palpebral ptosis in mice at 25 mg/kg
| Schlagworte: | (R)-Pirlindole, 2,3,3aR,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole, methanesulfonate |
| Anwendung: | MAO-A inhibitor |
| CAS | 1821379-62-7 |
| MW: | 322.42 D |
ab 76,00 €
Alternariol monomethyl ether
Artikelnummer: Cay11307-1
Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 µg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 µM in HCT116...
| Schlagworte: | AME, NSC 638262, 3,7-dihydroxy-9-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one |
| Anwendung: | MOA-A inhibitor |
| CAS | 23452-05-3 |
| MW: | 272.3 D |
ab 173,00 €
Phenelzine (sulfate)
Artikelnummer: Cay23956-250
Phenelzine is an inhibitor of monoamine oxidase (MAO, IC50 = 0.9 µM using rat brain mitochondrial preparations). It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine,...
| Schlagworte: | NSC 170957, W-1544A, (2-phenylethyl)-hydrazine, monosulfate |
| Anwendung: | Monoamine oxidase (MAO) inhibitor |
| CAS | 156-51-4 |
| MW: | 234.3 D |
ab 126,00 €
Isoniazid
Artikelnummer: Cay20378-50
Isoniazid is an antibiotic that acts as a prodrug, being converted by bacterial catalase-peroxidases to form isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis. It is effective against several species of Mycobacterium, including M. tuberculosis.Formal Name: 4-pyridinecarboxylic acid, hydrazide....
| Schlagworte: | Isonicotinylhydrazide, NSC 9659, 4-pyridinecarboxylic acid, hydrazide |
| Anwendung: | Antibacterial, tuberculostatic, antibiotic, enoyl ACP reductase inhibitor, MAO inhibitor |
| CAS | 54-85-3 |
| MW: | 137.1 D |
ab 32,00 €
Safinamide (mesylate)
Artikelnummer: Cay21546-50
Safinamide is an inhibitor of monoamine oxidase B (MAO-B, IC50 = ~0.1 µM). It is selective for MAO-B over MAO-A (IC50 = >10 µM). It also inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 µM, respectively). Safinamide...
| Schlagworte: | EMD 1195686, FCE 26743, NW-1015, PNU-151774E, 2S-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide,... |
| Anwendung: | Reversible MAO-B inhibitor |
| CAS | 202825-46-5 |
| MW: | 398.4 D |
ab 97,00 €
R-(-)-Deprenyl (hydrochloride)
Artikelnummer: Cay15046-100
Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression. R-(-)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 µM) over MAO-A (Ki = 9.06 µM). In addition to finding use against depression, R-(-)-deprenyl provides neuroprotection...
| Schlagworte: | L-Deprenyl, Selegiline, (R)-N,alpha-dimethyl-N-2-propyn-1-yl-benzeneethanamine, monohydrochloride |
| Anwendung: | MAO inhibitor |
| CAS | 14611-52-0 |
| MW: | 223.7 D |
ab 51,00 €