Zu "K00274" wurden 182 Artikel gefunden!
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Iproniazid
Artikelnummer: Cay45450-100
Iproniazid is an inhibitor of monoamine oxidase A (MAO-A) and MAO-B (IC50s = 6.56 and 7.54 µM, respectively). It reduces immobility in an open swimming test in rats, indicating antidepressant-like activity, when administered at a dose of 10 mg/kg. Iproniazid (300 and 400 mg/kg) induces acute hepatic necrosis in...
| Schlagworte: | 2-(1-methylethyl)hydrazide, 4-pyridinecarboxylic acid |
| Anwendung: | MAO-A / MAO-B inhibitor |
| CAS | 54-92-2 |
| MW: | 179.22 D |
ab 35,00 €
Monoamine Oxidase A (MAO-A) Inhibitor Screening...
Artikelnummer: BPS-83909
Monoamine Oxidase A (MAO-A) Inhibitor Screening Fluorogenic Assay Kit is designed to measure human MAO-A activity for screening and profiling applications based on the fluorometric detection of H2O2, one of the byproducts generated during the oxidative deamination of MAO-A substrates. The assay kit comes in a...
| Schlagworte: | MAOA, Amine oxidase [flavin-containing] A, Monoamine oxidase type A |
| Anwendung: | Enzyme kinetics, small molecule inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
804,00 €
Anti-Recombinant MAO-A, clone A611
Artikelnummer: E-AN301895L.100
Monoamine oxidase A (MAO-A), a mitochondrial enzyme, catalyzes the degradation of monoamines. Studies show that increased expression of MAO-A promotes prostate cancer metastasis by activating the Shh-IL6-RANKL signaling network. In addition, MAO-A expression in adipose tissue macrophages is upregulated in aging,...
| Schlagworte: | Anti-MAOA, Anti-Monoamine oxidase type A, Anti-Amine oxidase [flavin-containing] A, Recombinant MAO-A Monoclonal Antibody |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 303,00 €
Alternariol monomethyl ether
Artikelnummer: Cay11307-1
Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 µg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 µM in HCT116...
| Schlagworte: | AME, NSC 638262, 3,7-dihydroxy-9-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one |
| Anwendung: | MOA-A inhibitor |
| CAS | 23452-05-3 |
| MW: | 272.3 D |
ab 173,00 €
Phenelzine (sulfate)
Artikelnummer: Cay23956-250
Phenelzine is an inhibitor of monoamine oxidase (MAO, IC50 = 0.9 µM using rat brain mitochondrial preparations). It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine,...
| Schlagworte: | NSC 170957, W-1544A, (2-phenylethyl)-hydrazine, monosulfate |
| Anwendung: | Monoamine oxidase (MAO) inhibitor |
| CAS | 156-51-4 |
| MW: | 234.3 D |
ab 126,00 €
Isoniazid
Artikelnummer: Cay20378-50
Isoniazid is an antibiotic that acts as a prodrug, being converted by bacterial catalase-peroxidases to form isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis. It is effective against several species of Mycobacterium, including M. tuberculosis.Formal Name: 4-pyridinecarboxylic acid, hydrazide....
| Schlagworte: | Isonicotinylhydrazide, NSC 9659, 4-pyridinecarboxylic acid, hydrazide |
| Anwendung: | Antibacterial, tuberculostatic, antibiotic, enoyl ACP reductase inhibitor, MAO inhibitor |
| CAS | 54-85-3 |
| MW: | 137.1 D |
ab 32,00 €
Safinamide (mesylate)
Artikelnummer: Cay21546-50
Safinamide is an inhibitor of monoamine oxidase B (MAO-B, IC50 = ~0.1 µM). It is selective for MAO-B over MAO-A (IC50 = >10 µM). It also inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 µM, respectively). Safinamide...
| Schlagworte: | EMD 1195686, FCE 26743, NW-1015, PNU-151774E, 2S-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide,... |
| Anwendung: | Reversible MAO-B inhibitor |
| CAS | 202825-46-5 |
| MW: | 398.4 D |
ab 97,00 €
Bifemelane (hydrochloride)
Artikelnummer: Cay43732-10
Bifemelane is an inhibitor of monoamine oxidase A (MAO-A, Ki = 4.2 µM). It is selective for MAO-A over MAO-B (Ki = 46 µM). Bifemelane (15 mg/kg, p.o.) protects against ischemia-induced decreases in frontal cortex, hippocampus, and striatum levels of muscarinic acetylcholine receptors (mAChRs) in a rat model of...
| Schlagworte: | 4-(O-Benzylphenoxy)-N-methylbutylamine, BP-N-Methylbutylamine, MCI-2016,... |
| Anwendung: | MAO-A inhibitor |
| CAS | 62232-46-6 |
| MW: | 305.85 D |
ab 107,00 €
R-(-)-Deprenyl (hydrochloride)
Artikelnummer: Cay15046-100
Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression. R-(-)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 µM) over MAO-A (Ki = 9.06 µM). In addition to finding use against depression, R-(-)-deprenyl provides neuroprotection...
| Schlagworte: | L-Deprenyl, Selegiline, (R)-N,alpha-dimethyl-N-2-propyn-1-yl-benzeneethanamine, monohydrochloride |
| Anwendung: | MAO inhibitor |
| CAS | 14611-52-0 |
| MW: | 223.7 D |
ab 51,00 €
Clorgyline (hydrochloride)
Artikelnummer: Cay15925-10
Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin (Cay-14332) receptors, but it does inhibit the sigma receptor sigma1 on Jurkat human T lymphocyte...
| Schlagworte: | N-2,4-Dichlorophenoxypropyl-N-methylpropargylamine, N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine,... |
| Anwendung: | Potent monoamine oxidase (MAO) inhibitor |
| CAS | 17780-75-5 |
| MW: | 308.6 D |
ab 51,00 €
Amplite(TM) Fluorimetric Monoamine Oxidase Assay Kit *Red...
Artikelnummer: ABD-11303
Monoamine oxidases (MAO) are a family of flavin-containing amine oxidoreductases that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in numerous tissues including liver, intestinal mucosa, and nerves. In humans there are two types of MAO: MAO-A and MAO-B. MAO-A is...
| Anwendung: | Monoamine oxidase assays |
291,00 €
3,4-Dihydroxyphenylacetic Acid
Artikelnummer: Cay24912-5
3,4-dihydroxyphenylacetic acid (DOPAC) is a metabolite of dopamine (Cay-21992) formed through deamination by monoamine oxidase (MAO). DOPAC is further metabolized by catechol-O-methyltransferase (COMT) to form homovanillic acid, and DOPAC levels are increased 5- to 6-fold compared to wild-type in the nucleus...
| Schlagworte: | DOPAC, NSC 73191, 3,4-dihydroxy-benzeneacetic acid |
| Anwendung: | Dopamine metabolite |
| CAS | 102-32-9 |
| MW: | 168.1 D |
ab 114,00 €