DC-U4106

A USP8 inhibitor (IC50 = 1.2 µM), selective for USP8 over USP2 and USP7 (IC50s = 58.4 and >100 µM, respectively), induces apoptosis in, and inhibits colony formation by, MCF-7 cells from 1-5 µM, reduces tumor volume in an MCF-7 mouse xenograft model at 20 mg/kg. Formulation: A solid. InChI: InChI=1S/C29H27N5O5/c1-17-27(18(2)32-31-17)39-28-23(37)15-21(35)26-22(36)16-24(38-29(26)28)19-6-8-20(9-7-19)33-11-13-34(14-12-33)25-5-3-4-10-30-25/h3-10,15-16,35,37H,11-14H2,1-2H3,(H,31,32). InChIKey: VNWOJNLRTJFWRQ-UHFFFAOYSA-N. SMILES: O=C1C=C(C2=CC=C(N3CCN(CC3)C4=NC=CC=C4)C=C2)OC5=C1C(O)=CC(O)=C5OC6=C(C)NN=C6C