CP 673,451

CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor beta (PDGFRbeta) kinase with an IC50 value of 1 nM. It also inhibits the PDGFRalpha kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2. In several in vivo tumor models, CP-673,451 has antiangiogenic and antitumor activity.Formal Name: 1-[2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine. CAS Number: 343787-29-1. Molecular Formula: C24H27N5O2. Formula Weight: 417.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 274 nm. SMILES: NC(CC1)CCN1C2=CC=CC3=C2N=C(N4C=NC5=C4C=CC(OCCOC)=C5)C=C3. InChi Code: InChI=1S/C24H27N5O2/c1-30-13-14-31-19-6-7-21-20(15-19)26-16-29(21)23-8-5-17-3-2-4-22(24(17)27-23)28-11-9-18(25)10-12-28/h2-8,15-16,18H,9-14,25H2,1H3. InChi Key: DEEOXSOLTLIWMG-UHFFFAOYSA-N.