Zu "K05089" wurden 229 Artikel gefunden!
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Anti-Recombinant PDGFR-beta, clone 4B12
Artikelnummer: E-AN300813L.100
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a...
| Schlagworte: | Anti-PDGFRB, Anti-CD140 antigen-like family member B, Anti-Platelet-derived growth factor receptor 1, Anti-Beta... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
![PDGF R beta/CD140b[Biotin], His & Avi, Human](https://www.biomol.com/media/image/b7/6b/48/GSC-Z04584-100_200x200.png "PDGF R beta/CD140b[Biotin], His & Avi, Human")
PDGF R beta/CD140b[Biotin], His & Avi, Human
Artikelnummer: GSC-Z04584-100
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF...
| Schlagworte: | PDGFRB, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, Beta platelet-derived growth factor... |
| Ursprungsart: | human |
| MW: | 59 kD |
ab 887,00 €
PDGF R beta/CD140b, His, Canine
Artikelnummer: GSC-Z04712-100
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF...
| Schlagworte: | PDGFRB, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, Beta platelet-derived growth factor... |
| Ursprungsart: | dog |
| MW: | 57.25 kD |
ab 524,00 €
PDGF R beta/CD140b, His & Avi, Human
Artikelnummer: GSC-Z05738-100
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF...
| Schlagworte: | PDGFRB, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, Beta platelet-derived growth factor... |
| Ursprungsart: | human |
| MW: | 59 kD |
ab 376,00 €
PDGF R beta/CD140b, His, Rat
Artikelnummer: GSC-Z06428-100
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF...
| Schlagworte: | Pdgfrb, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, Beta platelet-derived growth factor... |
| Ursprungsart: | rat |
| MW: | 57.36 kD |
ab 578,00 €
Sorafenib
Artikelnummer: LKT-S5868.100
c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.
| Schlagworte: | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide |
| Anwendung: | BRAF / FLT3 / PDGFRB / VEGFR2 / VEGFR3 / c-KIT inhibitor |
| CAS | 284461-73-0 |
| MW: | 464.82 D |
ab 109,00 €
JNJ-10198409
Artikelnummer: Cay10008131-1
Inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (PDGF-BB) receptor can have potent antiangiogenic and antiproliferative activity. JNJ-10198409 is a small molecule inhibitor of platelet-derived growth factor (PDGF-BB) tyrosine kinase with an IC50 value...
| Schlagworte: | N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine |
| Anwendung: | PDGF-BB inhibitor |
| CAS | 627518-40-5 |
| MW: | 325.3 D |
ab 42,00 €
CP 673,451
Artikelnummer: Cay19170-1
CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor beta (PDGFRbeta) kinase with an IC50 value of 1 nM. It also inhibits the PDGFRalpha kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2. In several in...
| Schlagworte: | 1-[2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
| Anwendung: | PDGFRbeta inhibitor |
| CAS | 343787-29-1 |
| MW: | 417.5 D |
ab 67,00 €
SU 6668
Artikelnummer: Cay13873-1
SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRbeta, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 µM, respectively) but not EGFR (IC50 >100 µM). Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of...
| Schlagworte: | NSC 702827, Orantinib, TSU-68, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 252916-29-3 |
| MW: | 310.4 D |
ab 48,00 €
Crenolanib
Artikelnummer: Cay18873-5
Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor alpha (PDGFRalpha) and PDGFRbeta and Fms-related tyrosine kinase 3 (FLT3, IC50s = 11, 3.2, and 4 nM, respectively). It also inhibits medically-relevant...
| Schlagworte: | CP 868,596, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
| Anwendung: | PDGFR tyrosine kinase inhibitor |
| CAS | 670220-88-9 |
| MW: | 443.5 D |
ab 71,00 €
Dasatinib
Artikelnummer: TGM-T1448-50mg
Description: Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16/30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma. Target: c-Kit, Autophagy, Bcr-Abl, Apoptosis, Src. Smiles:...
| Schlagworte: | BMS-354825 |
| Anwendung: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 302962-49-8 |
| MW: | 488.01 D |
ab 36,00 €
AG-370
Artikelnummer: Cay10010568-5
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF)...
| Schlagworte: | NSC 651712, 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile |
| Anwendung: | PDGF receptor kinase inhibitor |
| CAS | 134036-53-6 |
| MW: | 259.3 D |
ab 85,00 €