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Zu "K05089" wurden 188 Artikel gefunden!
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Artikelnummer: Cay38765-1
X-82 is a multi-kinase inhibitor. It inhibits VEGFR2, PDGFRbeta, FMS-related tyrosine kinase 3 (FLT3), and c-Kit (IC50s = 1.12, 0.13, 0.63, and 0.14 nM, respectively) and is selective for these kinases over RET and AMP-activated kinase alpha1 (AMPKalpha1, IC50s = 74.1 and 352.2 nM, respectively). X-82 inhibits...
Schlagworte: | CM082, Vorolanib,... |
Anwendung: | Multi-kinase inhibitor |
CAS | 1013920-15-4 |
MW: | 439.5 D |
ab 106,00 €
Artikelnummer: Cay39831-1
CYY292 is an inhibitor of PDGFRalpha, PDGFRbeta, FGFR1, -2, and -3, (IC50s = 5.35, 4.6, 28, 28, and 78 nM, respectively). It is selective for these kinases over FGFR4 (IC50 = >1,000 nM) but also inhibits c-Kit, VEGFR2, VEGFR1, and insulin-like growth factor 1 receptor (IGF-1R, IC50s = 67, 33, 36, and 75 nM,...
Schlagworte: | N4-1H-indazol-6-yl-N2-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-5-methyl-2,4-pyrimidinediamine |
Anwendung: | PDGFR/FGFR inhibitor |
CAS | 2644673-04-9 |
MW: | 444.5 D |
ab 66,00 €
Artikelnummer: ELK-ELK7580.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PDGFRb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PDGFRb. Next,...
Schlagworte: | Pdgfr, Pdgfrb, CD140b, PDGFR-1, PDGFR-beta, PDGF-R-beta, EC=2.7.10.1, CD140 antigen-like family member B, Platelet-derived... |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
ab 365,00 €
Artikelnummer: ELK-ELK2769.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PDGFRb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PDGFRb....
Schlagworte: | PDGFR, PDGFRB, CD140b, PDGFR-1, PDGFR-beta, PDGF-R-beta, EC=2.7.10.1, CD140 antigen-like family member B, Platelet-derived... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay37754-10
Seralutinib is an inhibitor of PDGFR, c-Kit, and colony stimulating factor 1 receptor (CSF1R). It inhibits PDGF-BB-induced phosphorylation of ERK in PDGFRalpha-dependent H1703 human lung epithelial cells, human pulmonary arterial smooth muscle cells (HPASMCs), which express PDGFRalpha and PDGFRbeta, and human lung...
Schlagworte: | GB002, PK 10571, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl-3-pyridinecarboxamide |
Anwendung: | PDGFR / c-Kit / CSF1R inhibitor |
CAS | 1619931-27-9 |
MW: | 469.5 D |
ab 130,00 €
Artikelnummer: LKT-S5868.100
c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.
Schlagworte: | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide |
Anwendung: | BRAF / FLT3 / PDGFRB / VEGFR2 / VEGFR3 / c-KIT inhibitor |
CAS | 284461-73-0 |
MW: | 464.82 D |
ab 104,00 €
Artikelnummer: Cay10008131-1
Inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (PDGF-BB) receptor can have potent antiangiogenic and antiproliferative activity. JNJ-10198409 is a small molecule inhibitor of platelet-derived growth factor (PDGF-BB) tyrosine kinase with an IC50 value...
Schlagworte: | N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine |
Anwendung: | PDGF-BB inhibitor |
CAS | 627518-40-5 |
MW: | 325.3 D |
ab 38,00 €
Artikelnummer: Cay19170-1
CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor beta (PDGFRbeta) kinase with an IC50 value of 1 nM. It also inhibits the PDGFRalpha kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2. In several in...
Schlagworte: | 1-[2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
Anwendung: | PDGFRbeta inhibitor |
CAS | 343787-29-1 |
MW: | 417.5 D |
ab 60,00 €
Artikelnummer: Cay13873-1
SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRbeta, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 µM, respectively) but not EGFR (IC50 >100 µM). Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of...
Schlagworte: | NSC 702827, Orantinib, TSU-68, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid |
Anwendung: | Tyrosine kinase inhibitor |
CAS | 252916-29-3 |
MW: | 310.4 D |
ab 42,00 €
Artikelnummer: Cay10010568-5
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF)...
Schlagworte: | NSC 651712, 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile |
Anwendung: | PDGF receptor kinase inhibitor |
CAS | 134036-53-6 |
MW: | 259.3 D |
ab 77,00 €
Artikelnummer: Cay18873-5
Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor alpha (PDGFRalpha) and PDGFRbeta and Fms-related tyrosine kinase 3 (FLT3, IC50s = 11, 3.2, and 4 nM, respectively). It also inhibits medically-relevant...
Schlagworte: | CP 868,596, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
Anwendung: | PDGFR tyrosine kinase inhibitor |
CAS | 670220-88-9 |
MW: | 443.5 D |
ab 64,00 €
Artikelnummer: Cay14529-1
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the...
Schlagworte: | NSC 380341, Tyrphostin AG-1295, 6,7-dimethyl-2-phenyl-quinoxaline |
Anwendung: | PDGF receptor kinase inhibitor |
CAS | 71897-07-9 |
MW: | 234.3 D |
ab 43,00 €