Zu "K05089" wurden 242 Artikel gefunden!
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PDGFRbeta Inhibition Reporter Assay System (human)
Artikelnummer: IB-IB23201
Protein Function: Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an...
| Schlagworte: | PDGFRB, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, Beta platelet-derived growth factor... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
Anti-Recombinant PDGFR-beta, clone 4B12
Artikelnummer: E-AN300813L.100
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a...
| Schlagworte: | Anti-PDGFRB, Anti-CD140 antigen-like family member B, Anti-Platelet-derived growth factor receptor 1, Anti-Beta... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 257,00 €
Sorafenib
Artikelnummer: LKT-S5868.100
c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.
| Schlagworte: | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide |
| Anwendung: | BRAF / FLT3 / PDGFRB / VEGFR2 / VEGFR3 / c-KIT inhibitor |
| CAS | 284461-73-0 |
| MW: | 464.82 D |
ab 109,00 €
JNJ-10198409
Artikelnummer: Cay10008131-1
Inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (PDGF-BB) receptor can have potent antiangiogenic and antiproliferative activity. JNJ-10198409 is a small molecule inhibitor of platelet-derived growth factor (PDGF-BB) tyrosine kinase with an IC50 value...
| Schlagworte: | N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine |
| Anwendung: | PDGF-BB inhibitor |
| CAS | 627518-40-5 |
| MW: | 325.3 D |
ab 44,00 €
CP 673,451
Artikelnummer: Cay19170-1
CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor beta (PDGFRbeta) kinase with an IC50 value of 1 nM. It also inhibits the PDGFRalpha kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2. In several in...
| Schlagworte: | 1-[2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
| Anwendung: | PDGFRbeta inhibitor |
| CAS | 343787-29-1 |
| MW: | 417.5 D |
ab 69,00 €
SU 6668
Artikelnummer: Cay13873-1
SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRbeta, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 µM, respectively) but not EGFR (IC50 >100 µM). Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of...
| Schlagworte: | NSC 702827, Orantinib, TSU-68, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 252916-29-3 |
| MW: | 310.4 D |
ab 49,00 €
Crenolanib
Artikelnummer: Cay18873-5
Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor alpha (PDGFRalpha) and PDGFRbeta and Fms-related tyrosine kinase 3 (FLT3, IC50s = 11, 3.2, and 4 nM, respectively). It also inhibits medically-relevant...
| Schlagworte: | CP 868,596, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
| Anwendung: | PDGFR tyrosine kinase inhibitor |
| CAS | 670220-88-9 |
| MW: | 443.5 D |
ab 73,00 €
Dasatinib
Artikelnummer: TGM-T1448-50mg
Description: Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16/30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma. Target: c-Kit, Autophagy, Bcr-Abl, Apoptosis, Src. Smiles:...
| Schlagworte: | BMS-354825 |
| Anwendung: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 302962-49-8 |
| MW: | 488.01 D |
ab 36,00 €
AG-370
Artikelnummer: Cay10010568-5
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF)...
| Schlagworte: | NSC 651712, 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile |
| Anwendung: | PDGF receptor kinase inhibitor |
| CAS | 134036-53-6 |
| MW: | 259.3 D |
ab 89,00 €
AG-1295
Artikelnummer: Cay14529-1
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the...
| Schlagworte: | NSC 380341, Tyrphostin AG-1295, 6,7-dimethyl-2-phenyl-quinoxaline |
| Anwendung: | PDGF receptor kinase inhibitor |
| CAS | 71897-07-9 |
| MW: | 234.3 D |
ab 51,00 €
Anti-PDGFR-beta
Artikelnummer: E-AB-32531.20
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a...
| Schlagworte: | Anti-PDGFR, Anti-PDGFRB, Anti-CD140b, Anti-PDGFR-1, Anti-PDGFR-beta, EC=2.7.10.1, Anti-PDGF-R-beta, Anti-CD140... |
| Anwendung: | WB, IHC (paraffin), IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Imatinib free base
Artikelnummer: LKT-I4800.25
Inhibitor of Abl, c-Kit, and PDGFR.
| Anwendung: | Bcr-Abl / PDGFRA / PDGFRB / c-KIT tyrosine kinase inhibitor |
| CAS | 152459-95-5 |
| MW: | 493.62 D |
ab 87,00 €