COTI-2

Description: COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity. Target: Apoptosis, p53. Smiles: S=C(N\N=C1/CCCc2cccnc12)N1CCN(CC1)c1ccccn1. References: Bykov VJN,etal.Targeting mutant p53 for efficient cancer therapy.Nat Rev Cancer. 2018 Feb,18(2):89-102.