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COTI-2
Artikelnummer: TGM-T4325-100mg
Description: COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity. Target: Apoptosis, p53. Smiles: S=C(N\N=C1/CCCc2cccnc12)N1CCN(CC1)c1ccccn1. References: Bykov VJN,etal.Targeting mutant p53 for efficient cancer therapy.Nat Rev...
| Schlagworte: | COTI2, COTI 2 |
| Anwendung: | Mutant p53 activator |
| CAS | 1039455-84-9 |
| MW: | 366.48 D |
ab 40,00 €
COTI-2
Artikelnummer: Cay20031-1
COTI-2 is an orally available thiosemicarbazone that activates mutant forms of p53. It induces apoptosis in a wide variety of human tumor cells in culture, inhibits the proliferation of colorectal cancer cell lines more effectively than cetuximab and erlotinib (Cay-10483), and is active against human glioblastoma...
| Schlagworte: | 4-(2-pyridinyl)-2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide-1-piperazinecarbothioic acid |
| Anwendung: | Mutant p53 activator |
| CAS | 1039455-84-9 |
| MW: | 366.5 D |
ab 44,00 €
