Colchicine-d6

Colchicine-d6 is intended for use as an internal standard for the quantification of colchicine (Cay-9000760) by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 µM) that binds to tubulin, which disrupts spindle formation during mitosis. It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 µmol/kg in a mouse model of gout and preventing the deposition of uric acid.Formal Name: (S)-N-(1,2,3-trimethoxy-10-(methoxy-d3)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide-2,2,2-d3. CAS Number: 1217651-73-4. Molecular Formula: C22H19D6NO6. Formula Weight: 405.5. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: COC1=C(OC)C(OC)=CC2=C1C(C([C@@H](NC(C([2H])([2H])[2H])=O)CC2)=C3)=CC=C(OC([2H])([2H])[2H])C3=O. InChi Code: InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1/i1D3,2D3. InChi Key: IAKHMKGGTNLKSZ-BLYUGYDFSA-N.