CK1-IN-1

CK1-IN-1 is an inhibitor of casein kinase 1delta (CK1delta) and CK1epsilon (IC50s = 15 and 16 nM, respectively). It is selective for CK1delta and CK1epsilon over TGF-beta receptor type 1 (ALK5, IC50 = 151.8 nM) and TGF-beta receptor type 2 (TGFBR2) at 1 µM.Formal Name: 4-[2-(1-fluoro-2-naphthalenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-pyridine. CAS Number: 1784751-20-7. Synonyms: Casein Kinase 1 Inhibitor 1, CK1 Inhibitor 1. Molecular Formula: C24H15F2N3. Formula Weight: 383.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 1 mg/ml. lambdamax: 226, 279, 317 nm. SMILES: FC1=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=CC5=C1C=CC=C5. InChi Code: InChI=1S/C24H15F2N3/c25-18-8-5-16(6-9-18)22-23(17-11-13-27-14-12-17)29-24(28-22)20-10-7-15-3-1-2-4-19(15)21(20)26/h1-14H,(H,28,29). InChi Key: PUQAFIILJICJRR-UHFFFAOYSA-N.