Ciprostene (calcium salt)

Description: Ciprostene is the 9beta-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 µg/kg/min and 60 ng/ml, respectively. Target: Others. Smiles: [CaH2].[H][C@]12C\C(C[C@@]1(C)C[C@@H](O)[C@@H]2\C=C\[C@@H](O)CCCCC)=C\CCCC(O)=O.[H][C@]12C\C(C[C@@]1(C)C[C@@H](O)[C@@H]2\C=C\[C@@H](O)CCCCC)=C\CCCC(O)=O