Zu "K04263" wurden 38 Artikel gefunden!
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NEU
RO3244794
Artikelnummer: Cay25350-1
An IP receptor antagonist (Ki = 20 nM in isolated human platelets), selective for the IP receptor over a panel of 50 receptors at 10 µM but does bind to EP3, EP4, and TP receptors and the adenosine A3 receptor (Kis = 4,169, 1,820, 8,128, and 4,786 nM, respectively), inhibits carbaprostacyclin-induced cAMP...
| Schlagworte: | 4-fluoro-N-[[[5-(4-fluorophenyl)-2-benzofuranyl]methoxy]carbonyl]-D-phenylalanine |
| Anwendung: | IP receptor antagonist |
| CAS | 361457-01-4 |
| MW: | 451.42 D |
ab 227,00 €
NEU
Anti-Transferrin Receptor Protein 1/CD71 DyLight(R) 650...
Artikelnummer: Cay44497-100
Immunogen: Purified membrane fractions from OCI-LY7 cells Host: Mouse Species Reactivity: (+) Human Cross Reactivity: (+) TfR1 Applications: IC, FC. SMILES: . InChi Code: . InChi Key:
| Schlagworte: | Cluster of Differentiation 71, p90, TfR1, TFRC |
| Anwendung: | IF, FC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
512,00 €
CHO-K1/IP1/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00310
Recombinant CHO-K1 cells stably overexpress human prostaglandin I2 receptor (PTGIR) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.
| Schlagworte: | PTGIR, Prostacyclin receptor, Prostanoid IP receptor, Prostaglandin I2 receptor |
11.424,00 €
MRE-269-d6
Artikelnummer: Cay43917-1
MRE-269-d6 is intended for use as an internal standard for the quantification of MRE-269 (Cay-10010412) by GC- or LC-MS. MRE-269 is an IP receptor agonist and an active metabolite of NS 304 (Cay-10010411). It is formed from NS 304 primarily via carboxylesterase 1 (CES1) in human liver microsomes and via CES2 in...
| Schlagworte: | ACT-333679-d6, 2-[4-[(5,6-diphenyl-2-pyrazinyl)[1-(methyl-d3)ethyl-2,2,2-d3]amino]butoxy]-acetic acid |
| Anwendung: | GC-MS, internal standard, quantification, IP receptor agonist |
| CAS | 1265295-56-4 |
| MW: | 425.56 D |
1.683,00 €
NS 304-d6
Artikelnummer: Cay43918-1
NS 304-d6 is intended for use as an internal standard for the quantification of NS 304 (Cay-10010411) by GC- or LC-MS. NS 304 is an IP receptor agonist and a prodrug form of MRE-269 (Cay-10010412). It binds to the IP receptor (Ki = 260 nM for the human receptor) and induces cAMP accumulation in CHO cells expressing...
| Schlagworte: | Selexipag-d6, 2-[4-[(5,6-diphenyl-2-pyrazinyl)[1-(methyl-d3)ethyl-2,2,2-d3]amino]butoxy]-N-(methylsulfonyl)-acetamide |
| Anwendung: | GC-MS, internal standard, quantification, IP receptor agonist |
| CAS | 1265295-92-8 |
| MW: | 502.66 D |
1.853,00 €
Treprostinil
Artikelnummer: Cay10162-1
Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by increasing pulmonary arterial and vascular resistance. Treprostinil is a stable analog of prostacyclin (Cay-18220) that is used clinically for the treatment of PPH under the trade name Remodulin(TM). The structural...
| Schlagworte: | BW 15AU, LRX 15, Rumodolin, U-62840, Uniprost,... |
| Anwendung: | Prostacyclin analog, prostaglandin I2 receptor agonist |
| CAS | 81846-19-7 |
| MW: | 390.5 D |
ab 145,00 €
Anti-IP Receptor (mouse)
Artikelnummer: Cay160070-1
The IP Receptor is a class A rhodopsin-like G protein-coupled receptor that mediates the actions of prostaglandin I2 (PGI2). The C-terminal intracellular tail of the IP receptor undergoes isoprenylation and palmitoylation that results in anchoring of the tail to the plasma membrane. The IP receptor is expressed in...
| Schlagworte: | Anti-Ptgir, Anti-PGI receptor, Anti-PGI receptor, Anti-PGI2 receptor, Anti-PGI2 receptor, Anti-Prostacyclin receptor,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | murine, rat |
468,00 €
Anti-IP Receptor (human)
Artikelnummer: Cay10005518-1
The IP Receptor is a class A rhodopsin-like G protein-coupled receptor that mediates the actions of prostaglandin I2 (PGI2). The C-terminal intracellular tail of the IP receptor undergoes isoprenylation and palmitoylation that results in anchoring of the tail to the plasma membrane. The IP receptor is expressed in...
| Schlagworte: | Anti-PTGIR, Anti-PRIPR, Anti-PGI receptor, Anti-PGI receptor, Anti-PGI2 receptor, Anti-PGI2 receptor, Anti-Prostacyclin... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, murine, rat |
468,00 €
Anti-IP Receptor
Artikelnummer: ARG56490.250
Protein function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. [The UniProt Consortium]
| Schlagworte: | Anti-Ptgir, Anti-PGI receptor, Anti-PGI2 receptor, Anti-Prostacyclin receptor, Anti-Prostanoid IP receptor,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
707,00 €
AMX12006
Artikelnummer: Cay39027-5
AMX12006 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 4.3 nM). It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10 µM for all). AMX12006 is cytotoxic to MCF-7 and 4T1 breast and CT26 colon cancer cells (IC50s = 46.73, 79.47, and 41.39 µM, respectively). It reduces...
| Schlagworte: | 4-[(1S)-1-[[[1-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1H-indol-2-yl]carbonyl]amino]ethyl]-benzoic acid |
| Anwendung: | EP4 receptor (prostaglandin E receptor 4) antagonist |
| CAS | 2639775-01-0 |
| MW: | 481.5 D |
ab 88,00 €
Human PTGIR (Prostacyclin Receptor) ELISA Kit
Artikelnummer: ELK-ELK4649.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PTGIR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PTGIR. Next,...
| Schlagworte: | PTGIR, PRIPR, PGI receptor, PGI2 receptor, Prostacyclin receptor, Prostanoid IP receptor, Prostaglandin I2 receptor |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
Iloprost-d4
Artikelnummer: Cay9000366-100
Iloprost-d4 is intended for use as an internal standard for the quantification of iloprost (Cay-18215) by GC- or LC-MS. Iloprost is an agonist of the IP receptor and the prostaglandin E2 (PGE2) receptor subtype EP1 and a derivative of PGI2. It selectively binds to IP and EP1 receptors (Ki = 11 nM for both) over EP2,...
| Schlagworte: | Ciloprost-d4,... |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, Prostaglandin I2 receptor agonist |
| MW: | 364.5 D |
ab 246,00 €