CHR-6494

CHR-6494 is a haspin protein kinase inhibitor (IC50 = 2 nM) selective over 27 other protein kinases, including Aurora B kinase (IC50 > 1 µM). Haspin is a kinase necessary for mitosis that selectively phosphorylates histone 3 at the threonine 3 residue (H3T3ph). CHR-6494 decreases phosphorylation of H3T3 and arrests the cell cycle in the G2/M phase, which leads to apoptosis. It showed promising results in a xenograft tumor model.Formal Name: 3-(1H-indazol-5-yl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine. CAS Number: 1333377-65-3. Molecular Formula: C16H16N6. Formula Weight: 292.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 213, 252, 335 nm. SMILES: CCCNC(C=C1)=NN2C1=NC=C2C3=CC(C=NN4)=C4C=C3. InChi Code: InChI=1S/C16H16N6/c1-2-7-17-15-5-6-16-18-10-14(22(16)21-15)11-3-4-13-12(8-11)9-19-20-13/h3-6,8-10H,2,7H2,1H3,(H,17,21)(H,19,20). InChi Key: CZZCAOGIEGXMBZ-UHFFFAOYSA-N.