CCT245737

Description: CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM), CCT245737 shows much less activity against Chk2 (IC50: 2440 nM). Target: Chk. Smiles: FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1. References: Osborne JD, et al. Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). J Med Chem. 2016 Jun 9,59(11):5221-37.