Zu "1489389-18-5" wurden 3 Artikel gefunden!
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CCT245737
Artikelnummer: Cay28775-5
CCT245737 is a potent inhibitor of checkpoint kinase 1 (Chk1, IC50 = 1.3 nM). It is selective for Chk1 over Chk2 (IC50 = 2,440 nM). CCT245737 inhibits G2 checkpoint arrest induced by etoposide (Cay-12092) in HT-29 colon cancer cells (IC50 = 30 nM). In vivo, CCT245737 (300 mg/kg) inhibits Chk1 autophosphorylation...
| Schlagworte: | 5-[[4-[[(2R)-2-morpholinylmethyl]amino]-5-(trifluoromethyl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile |
| Anwendung: | Potent Chk1 inhibitor |
| CAS | 1489389-18-5 |
| MW: | 379.3 D |
ab 161,00 €
CCT-245737
Artikelnummer: LKT-C104762.1
CHK1 inhibitor.
| Schlagworte: | CCT-245737, CCT 245737, CCT245737 |
| Anwendung: | CHK1 inhibitor |
| CAS | 1489389-18-5 |
| MW: | 379.35 D |
ab 123,00 €
CCT245737
Artikelnummer: TGM-T7080-100mg
Description: CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM), CCT245737 shows much less activity against Chk2 (IC50: 2440 nM). Target: Chk. Smiles: FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1. References: Osborne JD, et al. Multiparameter Lead Optimization to Give an Oral...
| Schlagworte: | SRA737 |
| Anwendung: | Potent Chk1 inhibitor |
| CAS | 1489389-18-5 |
| MW: | 379.34 D |
ab 32,00 €
