CCT241533 (hydrochloride)

CCT241533 is a selective inhibitor of checkpoint kinase 2 (Chk2, IC50 = 3 nM). In human cancer cell lines, CCT241533 blocks Chk2 activity and potentiates the cytotoxicity of the PARP inhibitors, rucaparib, AG-1447, (Cay-15643) and olaparib (Cay-10621).Formal Name: (3R,4S)-rel-4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol, monohydrochloride. CAS Number: 1431697-96-9. Molecular Formula: C23H27FN4O4 . HCl. Formula Weight: 479.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 500 µg/ml. lambdamax: 222, 255, 334 nm. SMILES: FC1=CC(C2=NC(N[C@@H]3CNC[C@H]3C(C)(O)C)=C(C=C(OC)C(OC)=C4)C4=N2)=C(O)C=C1.Cl. InChi Code: InChI=1S/C23H27FN4O4.ClH/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29,/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28),1H/t15-,17-,/m1./s1. InChi Key: LAKJUTZIXHTMPC-SSPJITILSA-N. License: Sold under license from Cancer Research Technology, LTD..