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Zu "K06641" wurden 94 Artikel gefunden!
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Artikelnummer: Cay17552-1
Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 µM). This compound has been used to target the role of Chk2 in cellular signaling in...
Schlagworte: | BML-277, C 3742, Checkpoint Kinase 2 Inhibitor II, 2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide |
Anwendung: | Checkpoint kinase 2 inhibitor |
CAS | 516480-79-8 |
MW: | 363.8 D |
ab 43,00 €
Artikelnummer: Cay11491-1
Actively proliferating cells experience blocks at certain checkpoints in the cell cycle when DNA damage is detected. These checkpoints allow for DNA damage repair before further cell cycle progression. Targeting signaling pathways to selectively inhibit repair at these checkpoints in tumor cells is of considerable...
Schlagworte: | 3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide |
Anwendung: | Checkpoint kinase (Chk) inhibitor |
CAS | 860352-01-8 |
MW: | 362.4 D |
ab 34,00 €
Artikelnummer: Cay19178-1
CCT241533 is a selective inhibitor of checkpoint kinase 2 (Chk2, IC50 = 3 nM). In human cancer cell lines, CCT241533 blocks Chk2 activity and potentiates the cytotoxicity of the PARP inhibitors, rucaparib, AG-1447, (Cay-15643) and olaparib (Cay-10621).Formal Name:...
Schlagworte: | (3R,4S)-rel-4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethano... |
Anwendung: | Chk2 inhibitor |
CAS | 1431697-96-9 |
MW: | 479 D |
ab 50,00 €
Artikelnummer: Cay21184-1
Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2, IC50 = 13.5 nM). It is selective for Chk2 over Chk1 (IC50 = 220.4 nM). It inhibits Chk2 autophosphorylation at the serine in position 516 in non-cancerous 184B5 cells that contain wild-type p53 and in MDA-MB-231 cells that contain mutated p53 when used at...
Schlagworte: | SC-203885, (5Z)-5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-azepino[3,4-b]indol-1(2H)-one |
Anwendung: | CHEK2 inhibitor |
CAS | 724708-21-8 |
MW: | 295.3 D |
ab 324,00 €
Artikelnummer: E-AB-20843.20
Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18'...
Schlagworte: | Anti-phospho-CDS1, Anti-phospho-hCds1, Anti-phospho-CHEK2, Anti-phospho-Hucds1, EC=2.7.11.1, Anti-phospho-Cds1 homolog,... |
Anwendung: | WB, IHC (paraffin), IF, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
Artikelnummer: ARG54652.50
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation,...
Schlagworte: | Anti-CDS1, Anti-CHEK2, Anti-hCds1, Anti-Hucds1, EC=2.7.11.1, Anti-Cds1 homolog, Anti-Checkpoint kinase 2, Anti-CHK2... |
Anwendung: | ELISA, WB, ICC, IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
520,00 €
Artikelnummer: ARG57316.100
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation,...
Schlagworte: | Anti-CDS1, Anti-CHEK2, Anti-hCds1, Anti-Hucds1, EC=2.7.11.1, Anti-Cds1 homolog, Anti-Checkpoint kinase 2, Anti-CHK2... |
Anwendung: | WB, IHC (paraffin), ICC, IF, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
624,00 €
Artikelnummer: A300-618A
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation,...
Schlagworte: | Anti-CDS1, Anti-hCds1, Anti-CHEK2, Anti-Hucds1, EC=2.7.11.1, Anti-Cds1 homolog, Anti-Checkpoint kinase 2, Anti-CHK2... |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: A300-619A
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation,...
Schlagworte: | Anti-CDS1, Anti-hCds1, Anti-CHEK2, Anti-Hucds1, EC=2.7.11.1, Anti-Cds1 homolog, Anti-Checkpoint kinase 2, Anti-CHK2... |
Anwendung: | WB, IP, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: A300-620A
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation,...
Schlagworte: | Anti-CDS1, Anti-hCds1, Anti-CHEK2, Anti-Hucds1, EC=2.7.11.1, Anti-Cds1 homolog, Anti-Checkpoint kinase 2, Anti-CHK2... |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: IHC-00043
Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation,...
Schlagworte: | Anti-CDS1, Anti-hCds1, Anti-CHEK2, Anti-Hucds1, EC=2.7.11.1, Anti-Cds1 homolog, Anti-Checkpoint kinase 2, Anti-CHK2... |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: BPS-40040
Active human Checkpoint kinase 2 (GenBank Accession No. NM_007194), full length, with N-terminal HIS-tag. MW=91kDa. Expressed in a Baculovirus infected Sf9 cell expression system.
Schlagworte: | CDS1, hCds1, CHEK2, Hucds1, EC=2.7.11.1, Cds1 homolog, Checkpoint kinase 2, CHK2 checkpoint homolog,... |
Anwendung: | Enzyme kinetics, inhibitor screening |
MW: | 91 kD |
525,00 €