CBR-5884

CBR-5884 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 33 µM. It does not affect other NAD+-dependent dehydrogenases, including lactate dehydrogenase and malate dehydrogenase 1. CBR-5884 inhibits the proliferation of cancer cells by blocking de novo serine synthesis and is selectively cytotoxic for cells with high serine biosynthetic activity.Formal Name: 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylic acid, ethyl ester. CAS Number: 681159-27-3. Molecular Formula: C14H12N2O4S2. Formula Weight: 336.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/mL, DMF:PBS (pH 7.2), (1:7): 0.12 mg/mL, DMSO: 14 mg/mL. lambdamax: 248, 318 nm. SMILES: O=C(C1=CC=CO1)NC2=C(SC#N)C(C)=C(C(OCC)=O)S2. InChi Code: InChI=1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17). InChi Key: QBVIRPJBDIZKBC-UHFFFAOYSA-N.