CBL0137 hydrochloride

Description: CBL0137 hydrochloride (Curaxin-137 hydrochloride) activates p53 and inhibits NF-kB (EC50: 0.37/0.47 µM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone FACT. Target: Others, NF-kappaB, p53. Smiles: Cl.CC(C)NCCn1c2ccc(cc2c2cc(ccc12)C(C)=O)C(C)=O. References: Gasparian AV,etal.Curaxins: anticancer compounds that simultaneously suppress NF-kappaB and activate p53 by targeting FACT.Sci Transl Med. 2011 Aug 10,3(95):95ra74.