BMS-1001

BMS-1001 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1, IC50 = 2.25 nM in a cell-free assay). It has been used in the synthesis of a proteolysis-targeting chimera (PROTAC) that drives PD-L1 degradation in MC-38 colon cancer cells. Conjugates containing BMS-1001 have been used as PET radiotracers for imaging PDL-1 expression in an A549-hPDL1 lung cancer mouse xenograft model.. SMILES: CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN[C@@H](C(O)=O)CO)C=C2C)C=CC=C1C(C=C4)=CC5=C4OCCO5. InChi Code: InChI=1S/C35H34N2O7/c1-22-13-28(18-37-30(19-38)35(39)40)33(43-20-25-6-3-5-24(14-25)17-36)16-32(22)44-21-27-7-4-8-29(23(27)2)26-9-10-31-34(15-26)42-12-11-41-31/h3-10,13-16,30,37-38H,11-12,18-21H2,1-2H3,(H,39,40)/t30-/m1/s1. InChi Key: UWNXGZKSIKQKAH-SSEXGKCCSA-N