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BMS-1001
Artikelnummer: Cay45922-1
BMS-1001 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1, IC50 = 2.25 nM in a cell-free assay). It has been used in the synthesis of a proteolysis-targeting chimera (PROTAC) that drives PD-L1 degradation in MC-38 colon cancer cells. Conjugates...
| Schlagworte: | N-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-5-methylphenyl]methyl]-D-s... |
| Anwendung: | PD-1/PD-L1 protein-protein interaction inhibitor |
| CAS | 2113650-03-4 |
| MW: | 594.66 D |
ab 124,00 €
BMS-1001
Artikelnummer: TGM-T8470-100mg
Description: BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay). Target: PD-1/PD-L1. Smiles: CC1=CC(CN[C@H](CO)C(O)=O)=C(OCC2=CC(=CC=C2)C#N)C=C1OCC1=C(C)C(=CC=C1)C1=CC2=C(OCCO2)C=C1. References: Skalniak L , Zak K M , Guzik K , et al....
| CAS | 2113650-03-4 |
| MW: | 594.7 D |
ab 53,00 €
