BL 918

BL 918 is an activator of unc-51-like autophagy activating kinase 1 (ULK1). It activates ULK1 with an EC50 value of 24.14 nM in an ADP-based kinase assay. BL 918 (5 µM) increases the levels of ULK1 phosphorylated at serine 317 (Ser317) or Ser555, reduces the level of ULK1 phosphorylated at Ser757, and induces autophagy in SH-SY5Y cells. It reduces motor dysfunction and increases the number of dopaminergic neurons in the striatum in a mouse model of Parkinson's disease induced by MPTP when administered at doses of 40 and 80 mg/kg.Formal Name: alphaR-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-benzeneacetamide. CAS Number: 2101517-69-3. Molecular Formula: C23H15F8N3OS. Formula Weight: 533.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 251 nm. SMILES: FC(C=C(C=C1)F)=C1NC([C@@H](C2=CC=CC=C2)NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)=O. InChi Code: InChI=1S/C23H15F8N3OS/c24-15-6-7-18(17(25)11-15)33-20(35)19(12-4-2-1-3-5-12)34-21(36)32-16-9-13(22(26,27)28)8-14(10-16)23(29,30)31/h1-11,19H,(H,33,35)(H2,32,34,36)/t19-/m1/s1. InChi Key: BDBWQANRZRCMMD-LJQANCHMSA-N.