Bavdegalutamide

Description: Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR). Bavdegalutamide can be used in studies about prostate cancer. Bavdegalutamide shows oral activity and selectivity and facilitates the ubiquitination and degradation of AR. Target: Androgen Receptor. Smiles: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC(F)=C(C2)N4CCN(CC5CCN(CC5)C6=CC=C(C(N[C@@H]7CC[C@@H](OC8=CC(Cl)=C(C#N)C=C8)CC7)=O)N=N6)CC4. References: Taavi Neklesa, et al. ARV-110: An androgen receptor PROTAC degrader for prostate cancer. American Association for Cancer Research. 2018. 78 (13): pp. 5236.