Batefenterol

Description: Batefenterol (TD-5959) (GSK961081, TD-5959) is a muscarinic receptor antagonist and beta2-adrenoceptor agonist. It displays high affinity for hM2, hM3 muscarinic and hbeta2-adrenoceptor (Ki:1.4/1.3/3.7 nM). Target: Adrenergic Receptor, AChR. Smiles: COc1cc(NC(=O)CCN2CCC(CC2)OC(=O)Nc2ccccc2-c2ccccc2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2nc(O)ccc12. References: Hegde SS, et al. Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and beta2-adrenoceptor agonist properties. J Pharmacol Exp Ther. 2014 Oct,351(1):190-9.