Batefenterol

Batefenterol is a muscarinic antagonist and beta2-adrenergic receptor (beta2-AR) agonist (Kis = 1.4, 1.3, and 3.7 nM, for hM2, hM3, and hbeta2-AR, respectively in a radioligand binding assay).{40016, 40017} Batefenterol exhibits potent hbeta2-AR agonist activity (EC50 = 0.29 nM) with 440- and 320-fold functional selectivity over hbeta1- and hbeta3-ARs, respectively. Batefenterol induces smooth muscle relaxation (EC50 = 11 nM) in isolated guinea pig tracheal tissue and inhibits bronchoconstrictor response in a guinea pig bronchoprotection assay (ED50 = 6.4 µg/ml).Formal Name: N-[1,1'-biphenyl]-2-yl-carbamic acid, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester. CAS Number: 743461-65-6. Synonyms: GSK961081, TD-5959. Molecular Formula: C40H42ClN5O7. Formula Weight: 740.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 254, 293 nm. SMILES: ClC1=C(N([H])C(CCN2CCC(OC(N(C3=C(C4=CC=CC=C4)C=CC=C3)[H])=O)CC2)=O)C=C(OC)C(CN(C[C@H](O)C5=C(C=CC(N6[H])=O)C6=C(O)C=C5)[H])=C1. InChi Code: InChI=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30(29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(16-19-46)53-40(51)44-32-10-6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H,15-20,23-24H2,1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1. InChi Key: URWYQGVSPQJGGB-DHUJRADRSA-N.