Barnidipine-d5 (hydrochloride)

Barnidipine-d5 (hydrochloride) is intended for use as an internal standard for the quantification of barnidipine (Cay-20448) by GC- or LC-MS. Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery. It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day. Formulations containing barnidipine have been used in the treatment of hypertension.Formal Name: (4S)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(3S)-1-((phenyl-d5)methyl)-3-pyrrolidinyl] ester, monohydrochloride. Synonyms: YM-09730-5-d5. Molecular Formula: C27H24D5N3O6 . HCl. Formula Weight: 533.0. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: CC1=C(C(O[C@@H]2CN(CC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])CC2)=O)[C@H](C(C(OC)=O)=C(C)N1)C4=CC([N+]([O-])=O)=CC=C4.Cl. InChi Code: InChI=1S/C27H29N3O6.ClH/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19,/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3,1H/t22-,25-,/m0./s1/i4D,5D,6D,8D,9D,. InChi Key: XEMPUKIZUCIZEY-MWQBNHTBSA-N.