Baloxavir

Baloxavir is an active metabolite of baloxavir marboxil (Cay-33214). It inhibits influenza virus cap-dependent endonuclease (CEN) and CEN/RNA-dependent RNA polymerase (CEN/RdRp) activities in cell-free assays (IC50s = 2.5 and 1.6 nM, respectively). Baloxavir reduces viral titers in MDCK cells infected with laboratory, clinical, or zoonotic strains of influenza A or B (EC50s = 0.46-6.5 nM).Formal Name: (12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,12,12a-tetrahydro-7-hydroxy-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione. CAS Number: 1985605-59-1. Synonyms: BXA, S-033447. Molecular Formula: C24H19F2N3O4S. Formula Weight: 483.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 1 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 260 nm. SMILES: O=C1C(N(C=C2)N([C@@H]3C4=CC=CC=C4SCC5=C(F)C(F)=CC=C53)[C@@]6([H])N1CCOC6)=C(O)C2=O. InChi Code: InChI=1S/C24H19F2N3O4S/c25-16-6-5-13-15(20(16)26)12-34-18-4-2-1-3-14(18)21(13)29-19-11-33-10-9-27(19)24(32)22-23(31)17(30)7-8-28(22)29/h1-8,19,21,31H,9-12H2/t19-,21+/m1/s1. InChi Key: FIDLLEYNNRGVFR-CTNGQTDRSA-N.