BADGE

PPARgamma is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis. Ligands for PPARgamma include antidiabetic drugs of the thiazolidinedione structural class, 15-deoxy-Delta12,14-prostaglandin J2 (Cay-18570), and NSAIDS. BADGE is a synthetic compound used in the production of polycarbonate and industrial plastics. This compound was recently identified as an antagonist of PPARgamma. BADGE binds to PPARgamma with an apparent Kd of 100 µM and interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.Formal Name: 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane. CAS Number: 1675-54-3. Synonyms: Bisphenol A diglycidyl ether, DGEBA, NSC 5022. Molecular Formula: C21H24O4. Formula Weight: 340.4. Purity: >85%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: Miscible, DMSO: Miscible, Ethanol: Miscible. lambdamax: 228, 277, 283 nm. SMILES: CC(C)(c1ccc(OCC2OC2)cc1)c1ccc(OCC2OC2)cc1. InChi Code: InChI=1S/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3. InChi Key: LCFVJGUPQDGYKZ-UHFFFAOYSA-N. Origin: Synthetic.