B-RAF Inhibitor 1 (hydrochloride)

B-RAF inhibitor 1 is an inhibitor of Raf kinases (Kis = 0.3, 1, and 1 nM for C-RAF, B-RAF, and B-RAFV600E, respectively). It is selective for the B-RAFV600E kinase domain over Lck, Tie2, KDR, and p38alpha (IC50s = 83, 120, 1,000, and >1,600 nM, respectively). B-RAF inhibitor 1 inhibits phosphorylation of ERK in A375 melanoma cells (IC50 = 1.8 nM). It reduces tumor growth in an A375 SQ2 mouse xenograft model (ED50 = 1.3 mg/kg per day) and induces 85% tumor regression when administered at a dose of 5 mg/kg per day for 14 days. B-RAF inhibitor 1 (5 and 10 mg/kg per day) increases tumor growth in a MIA PaCa-2 mouse xenograft model.Formal Name: N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine, dihydrochloride. CAS Number: 1191385-19-9. Molecular Formula: C26H19ClN8 . 2HCl. Formula Weight: 551.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1mg/mL, DMSO: 10mg/mL, DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL. lambdamax: 288, 364 nm. SMILES: CC1=C(C(C=CN=C2NC3=CC=C(Cl)C=C3)=C2C=C1)NC4=NC=CC=C4C5=C6C(N=CN6)=NC=N5.Cl.Cl. InChi Code: InChI=1S/C26H19ClN8.2ClH/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23,,/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33),2*1H. InChi Key: HRLQRNBAJCQMMG-UHFFFAOYSA-N.