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Anti-B-Raf (V600E), monoclonal
Anti-B-Raf (V600E), monoclonal

Artikelnummer: NB-26039

Concentration: 0.5 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. B-Raf is a member of the Raf family of Ser/Thr protein kinases. It functions downstream of Ras to regulate the MAP kinase signaling pathway. Mutations in the BRAF gene cause diseases. Inherited mutations in...
Schlagworte: Anti-p94, Anti-BRAF, Anti-BRAF1, EC=2.7.11.1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf,...
Anwendung: ELISA, WB, IHC, IP
669,00 €
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PLX4032
PLX4032

Artikelnummer: Cay10618-5

PLX4032 is an orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively). It inhibits cell proliferation in a variety of cell lines expressing B-Raf V600E and synergizes strongly with taxol, vinblastine, and oxaliplatin in inhibiting the...
Schlagworte: RG-7204, Ro 51-85426, Vemurafenib,...
Anwendung: B-Raf kinase (mutant V600E and wild type) inhibitor
CAS 918504-65-1
MW: 489.9 D
ab 49,00 €
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Dabrafenib
Dabrafenib

Artikelnummer: Cay16989-5

Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50s = 3.2 and 5 nM, respectively). It has been investigated in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors and is often combined...
Schlagworte: GSK2118436,...
Anwendung: B-Raf V600E inhibitor
CAS 1195765-45-7
MW: 519.6 D
ab 44,00 €
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PLX4720
PLX4720

Artikelnummer: Cay15142-1

The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of...
Schlagworte: Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Anwendung: BRAFV600E inhibitor
CAS 918505-84-7
MW: 413.8 D
ab 44,00 €
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NEU
Anti-B-RAF Rabbit
Anti-B-RAF Rabbit

Artikelnummer: Cay32251-100

Rapidly accelerated fibrosarcoma (Raf) kinase is a serine/threonine kinase and component of the MAPK/ERK signaling pathway. Upon activation by upstream RAS signaling, Raf dimerizes and phosphorylates MEK1 leading to activation of transcription factors for cell growth, proliferation, and survival. Raf exists as three...
Schlagworte: B-RAF Proto-oncogene, Proto-oncogene B-RAF, RAFB1, Serine/Threonine Kinase, V-Raf Murine Sarcoma Viral Oncogene Homolog B
Anwendung: IHC, WB
407,00 €
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PLX4720, Free Base
PLX4720, Free Base

Artikelnummer: LC-P-8900_100mg

Soluble in DMSO. PLX4720 is a kinase inhibitor with marked selectivity against B-Raf(V600E), with an IC50 of 13 nM. PLX4720 induced cell cycle arrest and apoptosis exclusively in B-Raf(V600E)-positive cells in melanoma models. In B-Raf(V600E)-dependent tumor xenograft models, PLX4720 caused significant tumor...
Schlagworte: Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Anwendung: B-Raf(V600E) inhibitor
CAS 918505-84-7
MW: 413.83 D
ab 77,00 €
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Anti-phospho-B Raf (Ser445)
Anti-phospho-B Raf (Ser445)

Artikelnummer: ARG42671.50

Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
Schlagworte: Anti-phospho-p94, Anti-phospho-BRAF, Anti-phospho-BRAF1, Anti-phospho-Proto-oncogene B-Raf,...
Anwendung: WB
Reaktivität: Human
439,00 €
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Anti-B Raf
Anti-B Raf

Artikelnummer: ARG42705.100

Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
Schlagworte: Anti-p94, Anti-BRAF, Anti-BRAF1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf, Anti-v-Raf murine...
Anwendung: WB
Reaktivität: Human, Mouse
505,00 €
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Anti-B Raf
Anti-B Raf

Artikelnummer: ARG42707.100

Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
Schlagworte: Anti-p94, Anti-BRAF, Anti-BRAF1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf, Anti-v-Raf murine...
Anwendung: IHC (paraffin), IP, WB
Reaktivität: Human, Mouse, Rat
505,00 €
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Anti-phospho-B Raf (Thr401)
Anti-phospho-B Raf (Thr401)

Artikelnummer: ARG42708.100

Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
Schlagworte: Anti-phospho-p94, Anti-phospho-BRAF, Anti-phospho-BRAF1, Anti-phospho-Proto-oncogene B-Raf,...
Anwendung: ICC, IF, IP, WB
Reaktivität: Human, Mouse, Rat
505,00 €
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Belvarafenib
Belvarafenib

Artikelnummer: Cay31460-10

Belvarafenib is an inhibitor of B-RAF and C-RAF (IC50s = 41, 7, and 2 nM for wild-type B-RAF, B-RAFV600E, and wild-type C-RAF, respectively). It is cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s = 57 and 69 nM, respectively), as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62...
Schlagworte: GDC-5573, HM95573,...
Anwendung: B-RAF / C-RAF inhibitor
CAS 1446113-23-0
MW: 478.9 D
ab 44,00 €
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Anti-B-RAFV600E
Anti-B-RAFV600E

Artikelnummer: Cay32188-100

Rapidly accelerated fibrosarcoma (Raf) kinase is a serine/threonine kinase and component of the MAPK/ERK signaling pathway. Upon activation by upstream RAS signaling, Raf dimerizes and phosphorylates MEK1 leading to activation of transcription factors for cell growth, proliferation, and survival. Raf exists as three...
Schlagworte: Anti-p94, Anti-BRAF, Anti-BRAF1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf, Anti-v-Raf murine...
Anwendung: ELISA, ICC, IHC, WB
Reaktivität: Human
682,00 €
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