Zu "K04365" wurden 193 Artikel gefunden!
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Anti-BRAF, clone CCG-2
Artikelnummer: NSJ-RQ5438
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The BRAF gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion....
| Schlagworte: | Anti-p94, Anti-BRAF1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf, Anti-v-Raf murine sarcoma... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €
Anti-phospho-BRAF (Thr401), clone IBE-2
Artikelnummer: NSJ-RQ5439
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The BRAF gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion....
| Schlagworte: | Anti-phospho-p94, Anti-phospho-BRAF1, Anti-phospho-Proto-oncogene B-Raf, Anti-phospho-Serine/threonine-protein kinase... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
AZ 304
Artikelnummer: Cay37580-1
AZ 304 is an inhibitor of B-RAF and B-RAF containing a valine-to-glutamate substitution at position 600 (B-RAFV600E, IC50s= 79 and 38 nM, respectively). It is selective for B-RAF and B-RAFV600E over MAP3K7 and C-terminal Src kinase (CSK) (IC50s = 6,400 and 7,050 nM, respectively), as well as insulin-like growth...
| Schlagworte: | 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-benzamide |
| Anwendung: | B-RAF / B-RAFV600E inhibitor |
| CAS | 942507-42-8 |
| MW: | 451.5 D |
ab 48,00 €
Human BRAF (B-Raf Proto Oncogene Serine/Threonine Protein...
Artikelnummer: ELK-ELK4445.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BRAF. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human BRAF. Next,...
| Schlagworte: | p94, BRAF1, Proto-oncogene B-Raf, Serine/threonine-protein kinase B-raf, v-Raf murine sarcoma viral oncogene homolog B1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Vemurafenib, Free Base (PLX4032, R7204, RG7204,...
Artikelnummer: LC-V-2800_10g
Soluble in DMSO at 100 mg/mL, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 25-50 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Schlagworte: | RG-7204, Ro 51-85426, Vemurafenib,... |
| Anwendung: | B-Raf kinase (mutant V600E and wild type) inhibitor |
| CAS | 918504-65-1 |
| MW: | 489,92 D |
ab 88,00 €
Anti-B-Raf (V600E), monoclonal
Artikelnummer: NB-26039
Concentration: 0.5 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. B-Raf is a member of the Raf family of Ser/Thr protein kinases. It functions downstream of Ras to regulate the MAP kinase signaling pathway. Mutations in the BRAF gene cause diseases. Inherited mutations in...
| Schlagworte: | Anti-p94, Anti-BRAF, Anti-BRAF1, EC=2.7.11.1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf,... |
| Anwendung: | ELISA, WB, IHC, IP |
| Wirt: | Mouse |
717,00 €
PLX4032
Artikelnummer: Cay10618-5
PLX4032 is an orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively). It inhibits cell proliferation in a variety of cell lines expressing B-Raf V600E and synergizes strongly with taxol, vinblastine, and oxaliplatin in inhibiting the...
| Schlagworte: | RG-7204, Ro 51-85426, Vemurafenib,... |
| Anwendung: | B-Raf kinase (mutant V600E and wild type) inhibitor |
| CAS | 918504-65-1 |
| MW: | 489.9 D |
ab 60,00 €
BRAF (V600E), human recombinant protein (GST-His-Tag)
Artikelnummer: BPS-40533
Human v-raf murine sarcoma viral oncogene homolog B1 (BRAF), GenBank Accession No. NM_004333, a.a. 417-end with Val-to-Glu mutation on a.a. 600 and N-terminal GST tag, MW=69 kDa, expressed in Sf9 insect cells via a baculovirus expression system. This mutation is often cited as V599E.
| Schlagworte: | p94, BRAF1, Proto-oncogene B-Raf, Serine/threonine-protein kinase B-raf, v-Raf murine sarcoma viral oncogene homolog B1, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 69 kD |
525,00 €
Dabrafenib
Artikelnummer: Cay16989-5
Dabrafenib is an ATP-competitive inhibitor of Raf kinases (IC50s = 0.64, 0.68, and 5 nM for wild-type B-RAF kinase, mutant B-RAFV600E, and wild-type C-RAF kinase, respectively). It also inhibits the tyrosine kinase-like kinases ALK5 and LIMK1 (IC50s = 11 and 15 nM, respectively) and the calcium/calmodulin-dependent...
| Schlagworte: | GSK2118436,... |
| Anwendung: | B-Raf V600E inhibitor |
| CAS | 1195765-45-7 |
| MW: | 519.6 D |
ab 48,00 €
PLX4720
Artikelnummer: Cay15142-1
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of...
| Schlagworte: | Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Anwendung: | BRAFV600E inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.8 D |
ab 60,00 €
Anti-BRAF
Artikelnummer: A301-695A
Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. [The UniProt Consortium]
| Schlagworte: | Anti-p94, Anti-BRAF, Anti-BRAF1, EC=2.7.11.1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf,... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-B-Raf (V600K), monoclonal
Artikelnummer: NB-26110
Concentration: 0.5 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. B-Raf is a member of the Raf family of Ser/Thr protein kinases. It functions downstream of Ras to regulate the MAP kinase signaling pathway. Mutations in the BRAF gene cause diseases. Inherited mutations in...
| Schlagworte: | Anti-p94, Anti-BRAF, Anti-BRAF1, EC=2.7.11.1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf,... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Mouse |
717,00 €