Zu "K04365" wurden 166 Artikel gefunden!
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Anti-B-Raf (V600E), monoclonal Artikelnummer: NB-26039
Concentration: 0.5 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. B-Raf is a member of the Raf family of Ser/Thr protein kinases. It functions downstream of Ras to regulate the MAP kinase signaling pathway. Mutations in the BRAF gene cause diseases. Inherited mutations in...
| Schlagworte: | Anti-p94, Anti-BRAF, Anti-BRAF1, EC=2.7.11.1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf,... |
| Anwendung: | ELISA, WB, IHC, IP |
669,00 €
PLX4032 Artikelnummer: Cay10618-5
PLX4032 is an orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively). It inhibits cell proliferation in a variety of cell lines expressing B-Raf V600E and synergizes strongly with taxol, vinblastine, and oxaliplatin in inhibiting the...
| Schlagworte: | RG-7204, Ro 51-85426, Vemurafenib,... |
| Anwendung: | B-Raf kinase (mutant V600E and wild type) inhibitor |
| CAS | 918504-65-1 |
| MW: | 489.9 D |
ab 49,00 €
Dabrafenib Artikelnummer: Cay16989-5
Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50s = 3.2 and 5 nM, respectively). It has been investigated in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors and is often combined...
| Schlagworte: | GSK2118436,... |
| Anwendung: | B-Raf V600E inhibitor |
| CAS | 1195765-45-7 |
| MW: | 519.6 D |
ab 44,00 €
PLX4720 Artikelnummer: Cay15142-1
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of...
| Schlagworte: | Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Anwendung: | BRAFV600E inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.8 D |
ab 44,00 €
NEU
Anti-B-RAF Rabbit Artikelnummer: Cay32251-100
Rapidly accelerated fibrosarcoma (Raf) kinase is a serine/threonine kinase and component of the MAPK/ERK signaling pathway. Upon activation by upstream RAS signaling, Raf dimerizes and phosphorylates MEK1 leading to activation of transcription factors for cell growth, proliferation, and survival. Raf exists as three...
| Schlagworte: | B-RAF Proto-oncogene, Proto-oncogene B-RAF, RAFB1, Serine/Threonine Kinase, V-Raf Murine Sarcoma Viral Oncogene Homolog B |
| Anwendung: | IHC, WB |
407,00 €
PLX4720, Free Base Artikelnummer: LC-P-8900_100mg
Soluble in DMSO. PLX4720 is a kinase inhibitor with marked selectivity against B-Raf(V600E), with an IC50 of 13 nM. PLX4720 induced cell cycle arrest and apoptosis exclusively in B-Raf(V600E)-positive cells in melanoma models. In B-Raf(V600E)-dependent tumor xenograft models, PLX4720 caused significant tumor...
| Schlagworte: | Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Anwendung: | B-Raf(V600E) inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.83 D |
ab 77,00 €
Anti-phospho-B Raf (Ser445) Artikelnummer: ARG42671.50
Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
| Schlagworte: | Anti-phospho-p94, Anti-phospho-BRAF, Anti-phospho-BRAF1, Anti-phospho-Proto-oncogene B-Raf,... |
| Anwendung: | WB |
| Reaktivität: | Human |
439,00 €
Anti-B Raf Artikelnummer: ARG42705.100
Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
| Schlagworte: | Anti-p94, Anti-BRAF, Anti-BRAF1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf, Anti-v-Raf murine... |
| Anwendung: | WB |
| Reaktivität: | Human, Mouse |
505,00 €
Anti-B Raf Artikelnummer: ARG42707.100
Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
| Schlagworte: | Anti-p94, Anti-BRAF, Anti-BRAF1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf, Anti-v-Raf murine... |
| Anwendung: | IHC (paraffin), IP, WB |
| Reaktivität: | Human, Mouse, Rat |
505,00 €
Anti-phospho-B Raf (Thr401) Artikelnummer: ARG42708.100
Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
| Schlagworte: | Anti-phospho-p94, Anti-phospho-BRAF, Anti-phospho-BRAF1, Anti-phospho-Proto-oncogene B-Raf,... |
| Anwendung: | ICC, IF, IP, WB |
| Reaktivität: | Human, Mouse, Rat |
505,00 €
Belvarafenib Artikelnummer: Cay31460-10
Belvarafenib is an inhibitor of B-RAF and C-RAF (IC50s = 41, 7, and 2 nM for wild-type B-RAF, B-RAFV600E, and wild-type C-RAF, respectively). It is cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s = 57 and 69 nM, respectively), as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62...
| Schlagworte: | GDC-5573, HM95573,... |
| Anwendung: | B-RAF / C-RAF inhibitor |
| CAS | 1446113-23-0 |
| MW: | 478.9 D |
ab 44,00 €
Anti-B-RAFV600E Artikelnummer: Cay32188-100
Rapidly accelerated fibrosarcoma (Raf) kinase is a serine/threonine kinase and component of the MAPK/ERK signaling pathway. Upon activation by upstream RAS signaling, Raf dimerizes and phosphorylates MEK1 leading to activation of transcription factors for cell growth, proliferation, and survival. Raf exists as three...
| Schlagworte: | Anti-p94, Anti-BRAF, Anti-BRAF1, Anti-Proto-oncogene B-Raf, Anti-Serine/threonine-protein kinase B-raf, Anti-v-Raf murine... |
| Anwendung: | ELISA, ICC, IHC, WB |
| Reaktivität: | Human |
682,00 €