AZD 8329

An 11beta-HSD1 inhibitor (IC50 = 9 nM for the human enzyme), selective for 11beta-HSD1 over 11beta-HSD2 and 17beta-HSD1 (IC50s = >30 µM for both), and over 17beta-HSD3 with less than 5% inhibition at 10 µM, prevents impairments in cardiac function in a minipig model of myocardial infarction at 50 mg/kg per day, repeated oral administration over seven days induces tachyphylaxis in rats. SMILES: CC(C)(C(N(C(C=C1)=CC=C1C(O)=O)N=C2)=C2C(NC3[C@H]4C[C@H](C5)C[C@@H]3C[C@H]5C4)=O)C. InChi Code: InChI=1S/C25H31N3O3/c1-25(2,3)22-20(13-26-28(22)19-6-4-16(5-7-19)24(30)31)23(29)27-21-17-9-14-8-15(11-17)12-18(21)10-14/h4-7,13-15,17-18,21H,8-12H2,1-3H3,(H,27,29)(H,30,31)/t14-,15+,17-,18+,21?. InChi Key: XWBXJBSVYVJAMZ-HNDAYGKNSA-N