ARS1620

ARS1620 is a covalent inhibitor of K-RASG12C (IC50 = G12C (IC50s = 150 nM) over H441, A549, and HCT116 cells expressing wild-type K-RAS (IC50s = >10 µM). ARS1620 (200 mg/kg) induces tumor regression in a MIA-PaCa2, but not an H441, mouse xenograft model. It also decreases tumor volume in patient-derived xenograft (PDX) mouse models expressing K-RASG12C, but not K-RASG12D or wild-type K-RAS.Formal Name: 1-[4-[(7S)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one. CAS Number: 1698055-85-4. Molecular Formula: C21H17ClF2N4O2. Formula Weight: 430.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: FC1=CC=CC(O)=C1C2=C(Cl)C=C(C(N3CCN(C(C=C)=O)CC3)=NC=N4)C4=C2F. InChi Code: InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25-11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2. InChi Key: ZRPZPNYZFSJUPA-UHFFFAOYSA-N.