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ARS1620
Artikelnummer: Cay27915-5
ARS1620 is a covalent inhibitor of K-RASG12C (IC50 = G12C (IC50s = 150 nM) over H441, A549, and HCT116 cells expressing wild-type K-RAS (IC50s = >10 µM). ARS1620 (200 mg/kg) induces tumor regression in a MIA-PaCa2, but not an H441, mouse xenograft model. It also decreases tumor volume in patient-derived xenograft...
| Schlagworte: | 1-[4-[(7S)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one |
| Anwendung: | Covalent K-RAS inhibitor |
| CAS | 1698055-85-4 |
| MW: | 430.8 D |
ab 181,00 €
ARS-1620
Artikelnummer: TGM-T7609-100mg
Description: ARS-1620 is a covalent inhibitor of K-RASG12C. Target: Ras. Smiles: Oc1cccc(F)c1-c1c(Cl)cc2c(ncnc2c1F)N1CCN(CC1)C(=O)C=C. References: Janes M R , Zhang J , Li L S , et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor[J]. Cell, 2018, 172(3):578-589.e17.
| Anwendung: | Covalent K-RAS inhibitor |
| CAS | 1698055-85-4 |
| MW: | 430.84 D |
ab 79,00 €
