Zu "K07827" wurden 111 Artikel gefunden!
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ML-162-yne
Artikelnummer: Cay40783-10
ML-162-yne is an alkyne derivative of ML-162 (Cay-20455). It has been used in the synthesis of the proteolysis-targeting chimera (PROTAC) and GPX4 degrader dGPX4.Formal Name: alpha-[(2-chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N -(2-phenylethyl)-2-thiopheneacetamide. CAS Number: 2883115-46-4....
| Schlagworte: | alpha-[(2-chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N -(2-phenylethyl)-2-thiopheneacetamide |
| Anwendung: | ML-162 alkyne derivative, PROTAC synthesis |
| CAS | 2883115-46-4 |
| MW: | 501.4 D |
ab 47,00 €
K-Ras(G12D) Isoform A (human, recombinant)
Artikelnummer: Cay40372-100
K-Ras is a small GTPase and member of the RAS family of GTPases with roles in apoptosis, as well as cell proliferation, survival, and migration. K-Ras is composed of a guanine nucleotide-binding domain containing an active site, an effector binding domain, and an isoform-specific C-terminal hypervariable region...
| Schlagworte: | KRAS, KRAS2, Ki-Ras, K-Ras 2, c-K-ras, c-Ki-ras, GTPase KRas, GTPase KRas, N-terminally processed |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 23 kD |
448,00 €
K-Ras(G12V) Isoform B (human, recombinant)
Artikelnummer: Cay40373-100
K-Ras is a small GTPase and member of the RAS family of GTPases with roles in apoptosis, as well as cell proliferation, survival, and migration. K-Ras is composed of a guanine nucleotide-binding domain containing an active site, an effector binding domain, and an isoform-specific C-terminal hypervariable region...
| Schlagworte: | KRAS, KRAS2, Ki-Ras, K-Ras 2, c-K-ras, c-Ki-ras, GTPase KRas, GTPase KRas, N-terminally processed |
| Anwendung: | Active |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 22 kD |
448,00 €
K-Ras(G12C) Isoform A (human, recombinant)
Artikelnummer: Cay40371-100
K-Ras is a small GTPase and member of the RAS family of GTPases with roles in apoptosis, as well as cell proliferation, survival, and migration. K-Ras is composed of a guanine nucleotide binding domain containing an active site, an effector binding domain, and an isoform-specific C-terminal hypervariable region,...
| Schlagworte: | KRAS, KRAS2, Ki-Ras, K-Ras 2, c-K-ras, c-Ki-ras, GTPase KRas, GTPase KRas, N-terminally processed |
| Ursprungsart: | human |
448,00 €
Rat KRAS (V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene...
Artikelnummer: ELK-ELK0390.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat KRAS. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat KRAS. Next,...
| Schlagworte: | Kras, Kras2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 352,00 €
Erastin
Artikelnummer: Cay17754-10
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
| Schlagworte: | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
| Anwendung: | Antitumor agent |
| CAS | 571203-78-6 |
| MW: | 547.1 D |
ab 60,00 €
Anti-Active Ras, monoclonal
Artikelnummer: NB-26909
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Small GTPases are a super-family of cellular signaling regulators. Ras belongs to the Ras sub-family of GTPases that regulate cell proliferation, cell motility, and gene transcription. GTP binding increases the...
| Schlagworte: | Anti-KRAS, Anti-KRAS2 |
| Anwendung: | IP, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | vertebrates |
717,00 €
Anti-Ras (G12D), monoclonal
Artikelnummer: NB-26036
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Ras (G12D) is one type of Ras missense mutations at the codon 12. Ras protein is a membrane-associated GTPase that regulates cell proliferation, differentiation, and survival. Ras G12D mutation results in...
| Schlagworte: | Anti-KRAS, Anti-KRAS2 |
| Anwendung: | ELISA, WB, IHC, IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | vertebrates |
717,00 €
Anti-Ras (G13D), monoclonal
Artikelnummer: NB-26038
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Ras (G13D) is one type of Ras missense mutations at the codon 13. Ras protein is a membrane-associated GTPase that regulates cell proliferation, differentiation, and survival. Ras G13D mutation results in...
| Schlagworte: | Anti-KRAS, Anti-KRAS2 |
| Anwendung: | ELISA, WB, IHC, IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | vertebrates |
717,00 €
ML-162
Artikelnummer: Cay20455-1
ML-162 is an inhibitor of glutathione peroxidase 4 (GPX4). It decreases GPX4 levels in MDA-MB-231 breast cancer cells, as well as the viability of BT-549 breast cancer cells, an effect that is enhanced by alpha-eleostearic acid (9(Z),11(E),13(E)-octadecatrienoic acid, Cay-10008349). ML-162 is also selectively lethal...
| Schlagworte: | alpha-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide |
| Anwendung: | GPX4 inhibitor, antitumor agent |
| CAS | 1035072-16-2 |
| MW: | 477.4 D |
ab 62,00 €
Farnesyl Thiosalicylic Acid Amide
Artikelnummer: Cay13175-5
Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) amide is an FTS derivative with an amide added to the carboxyl group. FTS amide inhibits the growth of PANC-1 and U87 tumor cells with IC50 values of 20 and 10 µM,...
| Schlagworte: | FTS Amide, Salirasib Amide, 2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]-benzamide |
| Anwendung: | Ras signaling inhibitor |
| CAS | 1092521-74-8 |
| MW: | 357.6 D |
ab 26,00 €
KRAS Isoform B Coupled Nucleotide Exchange Assay Kit
Artikelnummer: BPS-78583
The KRAS IsoformB Coupled Nucleotide Exchange Assay Kit is designed for screening and profiling of KRAS IsoformB antagonists/inhibitors by monitoring the binding of an effector protein such as the Ras binding domain of Raf1, (RBD-cRaf) to KRAS. With this kit, a few simple steps on a microtiter plate are required for...
| Schlagworte: | KRAS, KRAS2, |
| Anwendung: | Small molecule inhibitor/antagonist screening, HTS, mutated KRAS affecting compound counter-screening |
| Spezies-Reaktivität: | human |
1.965,00 €